CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017359
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase 40 
Protein Synonyms/Alias
 SINK-homologous serine/threonine-protein kinase; Sugen kinase 495; SgK495 
Gene Name
 STK40 
Gene Synonyms/Alias
 SGK495; SHIK 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
196VVEALHQKNIVHRDLubiquitination[1]
236VSEGDLLKDQRGSPAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May be a negative regulator of NF-kappa-B and p53- mediated gene transcription. 
Sequence Annotation
 DOMAIN 35 331 Protein kinase.
 NP_BIND 41 49 ATP (By similarity).
 ACT_SITE 196 196 Proton acceptor (By similarity).
 BINDING 66 66 ATP (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 435 AA 
Protein Sequence
MKRRASDRGA GETSARAKAL GSGISGNNAK RAGPFILALC AVGPRLGNSP VPSIVQCLAR 60
KDGTDDFYQL KILTLEERGD QGIESQEERQ GKMLLHTEYS LLSLLHTQDG VVHHHGLFQD 120
RTCEIVEDTE SSRMVKKMKK RICLVLDCLC AHDFSDKTAD LINLQHYVIK EKRLSERETV 180
VIFYDVVRVV EALHQKNIVH RDLKLGNMVL NKRTHRITIT NFCLGKHLVS EGDLLKDQRG 240
SPAYISPDVL SGRPYRGKPS DMWALGVVLF TMLYGQFPFY DSIPQELFRK IKAAEYTIPE 300
DGRVSENTVC LIRKLLVLDP QQRLAAADVL EALSAIIASW QSLSSLSGPL QVVPDIDDQM 360
SNADSSQEAK VTEECSQYEF ENYMRQQLLL AEEKSSIHDA RSWVPKRQFG SAPPVRRLGH 420
DAQPMTSLDT AILAQRYLRK 440 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR024236; Ser/Thr_kinase_40.
 IPR008271; Ser/Thr_kinase_AS.
 IPR024104; Tribbles/Ser_Thr_kinase_40. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS