UniProt Accession

 ACOD2_MOUSE; P13011; Q8BH96 

Genbank Protein ID

 M26270; AK083922; AK147406; CH466534; BC040384 

Genbank Nucleotide ID

 AAA40094.1; BAC39066.1; BAE27893.1; EDL41928.1; AAH40384.1 

Protein Name

 Acyl-CoA desaturase 2 

Protein Synonyms/Alias

 Delta(9)-desaturase 2; Delta-9 desaturase 2; Fatty acid desaturase 2; Stearoyl-CoA desaturase 2 

Gene Name

 Scd2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
161	RDHRAHHKFSETHAD	ubiquitination	[1]
198	AVKEKGGKLDMSDLK	ubiquitination	[1]
205	KLDMSDLKAEKLVMF	acetylation	[2]
205	KLDMSDLKAEKLVMF	ubiquitination	[1]
208	MSDLKAEKLVMFQRR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. 

Sequence Annotation

 MOTIF 119 124 Histidine box-1.
 MOTIF 156 160 Histidine box-2.
 MOTIF 297 301 Histidine box-3.  

Keyword

 Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Iron; Lipid biosynthesis; Lipid metabolism; Membrane; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 358 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004768; F:stearoyl-CoA 9-desaturase activity; IEA:EC.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR005804; Fatty_acid_desaturase-1.
 IPR001522; Fatty_acid_desaturase-1_C.
 IPR015876; Fatty_acid_desaturase-1_core. 

Pfam

 PF00487; FA_desaturase 

SMART

  

PROSITE

 PS00476; FATTY_ACID_DESATUR_1 

PRINTS

 PR00075; FACDDSATRASE.