CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019367
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CDK5 regulatory subunit-associated protein 3 
Protein Synonyms/Alias
 CDK5 activator-binding protein C53; Protein HSF-27 
Gene Name
 CDK5RAP3 
Gene Synonyms/Alias
 IC53; MSTP016; OK/SW-cl.114; PP1553 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
79EQFYHSCKQYGITGEubiquitination[1, 2]
308AILQGQTKEKMVTMVubiquitination[2]
370KKELMVQKQQEALEEubiquitination[2]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Potential regulator of CDK5 activity. May be involved in cell proliferation. Regulates CDK5 activity via its interaction with CDK5R1 (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 506 AA 
Protein Sequence
MCVHPGACLP HVGVSWAEFP GHFSVELSSL LVRNVNYEIP SLKKQIAKCQ QLQQEYSRKE 60
EECQAGAAEM REQFYHSCKQ YGITGENVRG ELLALVKDLP SQLAEIGAAA QQSLGEAIDV 120
YQASVGFVCE SPTEQVLPML RFVQKRGNST VYEWRTGTEP SVVERPHLEE LPEQVAEDAI 180
DWGDFGVEAV SEGTDSGISA EAAGIDWGIF PESDSKDPGG DGIDWGDDAV ALQITVLEAG 240
TQAPEGVARG PDALTLLEYT ETRNQFLDEL MELEIFLAQR AVELSEEADV LSVSQFQLAP 300
AILQGQTKEK MVTMVSVLED LIGKLTSLQL QHLFMILASP RYVDRVTEFL QQKLKQSQLL 360
ALKKELMVQK QQEALEEQAA LEPKLDLLLE KTKELQKLIE ADISKRYSGR PVNLMGTSL 419 
Gene Ontology
 GO:0019901; F:protein kinase binding; NAS:UniProtKB.
 GO:0007420; P:brain development; NAS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; ISS:UniProtKB.
 GO:0045664; P:regulation of neuron differentiation; NAS:UniProtKB. 
Interpro
 IPR008491; DUF773. 
Pfam
 PF05600; DUF773 
SMART
  
PROSITE
  
PRINTS