CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039960
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nuclear pore complex protein Nup133 
Protein Synonyms/Alias
  
Gene Name
 NUP133 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19TPRTASRKGLPLGSAubiquitination[1, 2, 3, 4]
66ESVNYDVKTFGSSLPubiquitination[3, 5]
119IALSPITKLSVCKELubiquitination[3, 4, 5]
223LIPESSGKIHQHILPubiquitination[3]
280LTSSNISKWELDDSSubiquitination[3]
289ELDDSSEKHAYSWDIubiquitination[3]
301WDINRALKENITDAIubiquitination[3, 6]
319ESNYEAIKEGVNIRYubiquitination[6]
502ETIAQEDKIKLLKAAubiquitination[3]
507EDKIKLLKAAFLQYCubiquitination[3]
588ILHQLEDKMKAHSFLubiquitination[3]
590HQLEDKMKAHSFLMDubiquitination[3]
658AILIALNKREYEIPSubiquitination[1, 3, 4, 5, 6, 7]
742RREESLEKEPEYVPWubiquitination[3, 4, 6]
771RQHEIVLKVAYPQADubiquitination[1, 3]
826LEMEYLQKRSDLLSPubiquitination[1, 2, 3, 4, 6, 7]
892LFRWYLEKGKRGKLLubiquitination[3]
897LEKGKRGKLLSQPISubiquitination[3]
951ETRYFAKKKTLLGLSubiquitination[3]
1033RANEYDFKKALDLLEubiquitination[3, 4]
1073NWSSSDGKDDPIEVSubiquitination[6]
1081DDPIEVSKDSIFVKIubiquitination[3]
1091IFVKILQKLLKDGIQubiquitination[3]
1094KILQKLLKDGIQLSEubiquitination[1, 3, 4, 6, 7]
1107SEYLPEVKDLLQADQubiquitination[7]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [7] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1140 AA 
Protein Sequence
MGPLAGLGPG STPRTASRKG LPLGSAVSSP VLFSPVGRRS SLSSRGTPTR MFPHHSITES 60
VNYDVKTFGS SLPVKVMEAL TLAEVDDQLT INIDEGGWAC LVCKEKLIIW KIALSPITKL 120
SVCKELQLPP SDFHWSADLV ALSYSSPSGE AHSTQAVAVM VATREGSIRY WPSLAGEDTY 180
TEAFVDSGGD KTYSFLTAVQ GGSFILSSSG SQLIRLIPES SGKIHQHILP QGQGMLSGIG 240
RKVSSLFGIL SPSSDLTLSS VLWDRERSSF YSLTSSNISK WELDDSSEKH AYSWDINRAL 300
KENITDAIWG SESNYEAIKE GVNIRYLDLK QNCDGLVILA AAWHSADNPC LIYYSLITIE 360
DNGCQMSDAV TVEVTQYNPP FQSEDLILCQ LTVPNFSNQT AYLYNESAVY VCSTGTGKFS 420
LPQEKIVFNA QGDSVLGAGA CGGVPIIFSR NSGLVSITSR ENVSILAEDL EGSLASSVAG 480
PNSESMIFET TTKNETIAQE DKIKLLKAAF LQYCRKDLGH AQMVVDELFS SHSDLDSDSE 540
LDRAVTQISV DLMDDYPASD PRWAESVPEE APGFSNTSLI ILHQLEDKMK AHSFLMDFIH 600
QVGLFGRLGS FPVRGTPMAT RLLLCEHAEK LSAAIVLKNH HSRLSDLVNT AILIALNKRE 660
YEIPSNLTPA DVFFREVSQV DTICECLLEH EEQVLRDAPM DSIEWAEVVI NVNNILKDML 720
QAASHYRQNR NSLYRREESL EKEPEYVPWT ATSGPGGIRT VIIRQHEIVL KVAYPQADSN 780
LRNIVTEQLV ALIDCFLDGY VSQLKSVDKS SNRERYDNLE MEYLQKRSDL LSPLLSLGQY 840
LWAASLAEKY CDFDILVQMC EQTDNQSRLQ RYMTQFADQN FSDFLFRWYL EKGKRGKLLS 900
QPISQHGQLA NFLQAHEHLS WLHEINSQEL EKAHATLLGL ANMETRYFAK KKTLLGLSKL 960
AALASDFSED MLQEKIEEMA EQERFLLHQE TLPEQLLAEK QLNLSAMPVL TAPQLIGLYI 1020
CEENRRANEY DFKKALDLLE YIDEEEDINI NDLKLEILCK ALQRDNWSSS DGKDDPIEVS 1080
KDSIFVKILQ KLLKDGIQLS EYLPEVKDLL QADQLGSLKS NPYFEFVLKA NYEYYVQGQI 1140 
Gene Ontology
  
Interpro
 IPR007187; Nucleoporin_Nup133/Nup155_C.
 IPR014908; Nucleoporin_Nup133/Nup155_N.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF03177; Nucleoporin_C
 PF08801; Nucleoporin_N 
SMART
  
PROSITE
  
PRINTS