| Tag | Content |
|---|
| CPLM ID | CPLM-015938 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kinesin-like protein KIF21A |
Protein Synonyms/Alias | Kinesin-like protein KIF2; Renal carcinoma antigen NY-REN-62 |
Gene Name | KIF21A |
Gene Synonyms/Alias | KIAA1708; KIF2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1038 | FLSMGINKGLQAAQK | ubiquitination | [1] | | 1045 | KGLQAAQKEAQIKVL | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity). |
Sequence Annotation | DOMAIN 1 299 Kinesin-motor.
REPEAT 1345 1382 WD 1.
REPEAT 1385 1423 WD 2.
REPEAT 1449 1487 WD 3.
REPEAT 1490 1532 WD 4.
REPEAT 1541 1578 WD 5.
REPEAT 1582 1621 WD 6.
REPEAT 1624 1661 WD 7.
NP_BIND 88 95 ATP (By similarity).
MOD_RES 80 80 Phosphotyrosine (By similarity).
MOD_RES 87 87 Phosphotyrosine (By similarity).
MOD_RES 524 524 Phosphoserine.
MOD_RES 1212 1212 Phosphoserine.
MOD_RES 1239 1239 Phosphoserine.
MOD_RES 1662 1662 Phosphoserine.
MOD_RES 1664 1664 Phosphothreonine.
MOD_RES 1673 1673 Phosphoserine. |
Keyword | Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Disease mutation; Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1674 AA |
Protein Sequence | MLGAPDESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ 60
QEQIYIQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIVEEE LGIISRAVKH 120
LFKSIEEKKH IAIKNGLPAP DFKVNAQFLE LYNEEVLDLF DTTRDIDAKS KKSNIRIHED 180
STGGIYTVGV TTRTVNTESE MMQCLKLGAL SRTTASTQMN VQSSRSHAIF TIHVCQTRVC 240
PQIDADNATD NKIISESAQM NEFETLTAKF HFVDLAGSER LKRTGATGER AKEGISINCG 300
LLALGNVISA LGDKSKRATH VPYRDSKLTR LLQDSLGGNS QTIMIACVSP SDRDFMETLN 360
TLKYANRARN IKNKVMVNQD RASQQINALR SEITRLQMEL MEYKTGKRII DEEGVESIND 420
MFHENAMLQT ENNNLRVRIK AMQETVDALR SRITQLVSDQ ANHVLARAGE GNEEISNMIH 480
SYIKEIEDLR AKLLESEAVN ENLRKNLTRA TARAPYFSGS STFSPTILSS DKETIEIIDL 540
AKKDLEKLKR KEKRKKKSVA GKEDNTDTDQ EKKEEKGVSE RENNELEVEE SQEVSDHEDE 600
EEEEEEEEDD IDGGESSDES DSESDEKANY QADLANITCE IAIKQKLIDE LENSQKRLQT 660
LKKQYEEKLM MLQHKIRDTQ LERDQVLQNL GSVESYSEEK AKKVRSEYEK KLQAMNKELQ 720
RLQAAQKEHA RLLKNQSQYE KQLKKLQQDV MEMKKTKVRL MKQMKEEQEK ARLTESRRNR 780
EIAQLKKDQR KRDHQLRLLE AQKRNQEVVL RRKTEEVTAL RRQVRPMSDK VAGKVTRKLS 840
SSDAPAQDTG SSAAAVETDA SRTGAQQKMR IPVARVQALP TPATNGNRKK YQRKGLTGRV 900
FISKTARMKW QLLERRVTDI IMQKMTISNM EADMNRLLKQ REELTKRREK LSKRREKIVK 960
ENGEGDKNVA NINEEMESLT ANIDYINDSI SDCQANIMQM EEAKEEGETL DVTAVINACT 1020
LTEARYLLDH FLSMGINKGL QAAQKEAQIK VLEGRLKQTE ITSATQNQLL FHMLKEKAEL 1080
NPELDALLGH ALQDLDSVPL ENVEDSTDED APLNSPGSEG STLSSDLMKL CGEVKPKNKA 1140
RRRTTTQMEL LYADSSELAS DTSTGDASLP GPLTPVAEGQ EIGMNTETSG TSAREKELSP 1200
PPGLPSKIGS ISRQSSLSEK KIPEPSPVTR RKAYEKAEKS KAKEQKHSDS GTSEASLSPP 1260
SSPPSRPRNE LNVFNRLTVS QGNTSVQQDK SDESDSSLSE VHRSSRRGII NPFPASKGIR 1320
AFPLQCIHIA EGHTKAVLCV DSTDDLLFTG SKDRTCKVWN LVTGQEIMSL GGHPNNVVSV 1380
KYCNYTSLVF TVSTSYIKVW DIRDSAKCIR TLTSSGQVTL GDACSASTSR TVAIPSGENQ 1440
INQIALNPTG TFLYAASGNA VRMWDLKRFQ STGKLTGHLG PVMCLTVDQI SSGQDLIITG 1500
SKDHYIKMFD VTEGALGTVS PTHNFEPPHY DGIEALTIQG DNLFSGSRDN GIKKWDLTQK 1560
DLLQQVPNAH KDWVCALGVV PDHPVLLSGC RGGILKVWNM DTFMPVGEMK GHDSPINAIC 1620
VNSTHIFTAA DDRTVRIWKA RNLQDGQISD TGDLGEDIAS N 1661 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005875; C:microtubule associated complex; IEA:InterPro. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0003777; F:microtubule motor activity; IEA:InterPro. GO:0007018; P:microtubule-based movement; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |