UniProt Accession

 HAUS2_HUMAN; Q9NVX0; C9JH36; Q9H9B3 

Genbank Protein ID

 AK001322; AK022939; AC018362; BC010903 

Genbank Nucleotide ID

 BAA91623.1; BAB14319.1; AAH10903.1 

Protein Name

 HAUS augmin-like complex subunit 2 

Protein Synonyms/Alias

 Centrosomal protein of 27 kDa 

Gene Name

 HAUS2 

Gene Synonyms/Alias

 C15orf25; CEP27 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
39	EMLNMSKKTVSCFVN	ubiquitination	[1]
63	IQAEIYQKNLEIELL	ubiquitination	[2]
71	NLEIELLKLEKDTAD	ubiquitination	[1, 2]
88	HPFFLAQKCHTLQSM	ubiquitination	[1]
115	SLRQRLLKPMCQENL	ubiquitination	[1]
192	ENILKWRKQQNEVSS	ubiquitination	[1]
213	AEESYLYKHDIIMPP	ubiquitination	[1, 2]
226	PPLPFTSKVHVQTIN	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. 

Sequence Annotation

  

Keyword

 Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 235 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0070652; C:HAUS complex; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0051297; P:centrosome organization; IMP:UniProtKB.
 GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0051225; P:spindle assembly; IMP:UniProtKB. 

Interpro

 IPR026242; HAUS2. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR02088; HAUSAUGMINL2.