CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041466
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Translation initiation factor eIF-2B subunit beta 
Protein Synonyms/Alias
  
Gene Name
 EIF2B2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MPGSAAKGSELSERubiquitination[1]
23ESFVETLKRGGGPRSubiquitination[1]
87NMVRRVLKIIREEYGubiquitination[1]
179RTVEAFLKEAARKRKubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 206 AA 
Protein Sequence
MPGSAAKGSE LSERIESFVE TLKRGGGPRS SEEMARETLG LLRQIITDHR WSNAGELMEL 60
IRREGRRMTA AQPSETTVGN MVRRVLKIIR EEYGRLHGRS DESDQQESLH KLLTSGGLNE 120
DFSFHYAQLQ SNIIEAINEL LVELEGTMEN IAAQALEHIH SNEVIMTIGF SRTVEAFLKE 180
AARKRKFHVI VAECAPFCQQ VLRQLS 206 
Gene Ontology
 GO:0044237; P:cellular metabolic process; IEA:InterPro. 
Interpro
 IPR000649; IF-2B-related. 
Pfam
 PF01008; IF-2B 
SMART
  
PROSITE
  
PRINTS