CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024349
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein AF-9 
Protein Synonyms/Alias
 Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog 
Gene Name
 Mllt3 
Gene Synonyms/Alias
 Af9 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
219REHKSAFKEPSRDHNacetylation[1]
254IVPKMAFKEPKPMSKacetylation[1, 2]
325ILTCSADKKQIKDKSacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (By similarity). 
Sequence Annotation
 DOMAIN 8 112 YEATS.
 MOTIF 296 301 Nuclear localization signal (Potential).
 MOD_RES 289 289 Phosphoserine (By similarity).
 MOD_RES 295 295 Phosphoserine (By similarity).
 MOD_RES 413 413 Phosphoserine (By similarity).
 MOD_RES 420 420 Phosphoserine (By similarity).
 MOD_RES 430 430 Phosphoserine (By similarity).
 MOD_RES 484 484 Phosphoserine (By similarity).  
Keyword
 Activator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 569 AA 
Protein Sequence
MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK VVFHLHESFP 60
RPKRVCKDPP YKVEESGYAG FILPIEVYFK NKEEPKKVRF DYDLFLHLEG HPPVNHLRCE 120
KLTFNNPTED FRRKLLKAGG DPNRSIHTSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS 180
SSSSSSSSSS TSFSKPHKLM KEHKEKPSKD SREHKSAFKE PSRDHNKSSK DSSKKPKENK 240
PLKEEKIVPK MAFKEPKPMS KEPKADSNLL TVTSGQQDKK APSKRPPASD SEELSAKKRK 300
KSSSEALFKS FSSAPPLILT CSADKKQIKD KSHVKMGKVK IESETSEKKK SMLPPFDDIV 360
DPNDSDVEEN MSSKSDSEQP SPASSSSSSS SSFTPSQTRQ QGPLRSIMKD LHSDDNEEES 420
DEAEDNDNDS EMERPVNRGG SRSRRVSLSD GSDSESSSAS SPLHHEPPPP LLKTNNNQIL 480
EVKSPIKQSK SDKQIKNGEC DKAYLDELVE LHRRLMTLRE RHILQQIVNL IEETGHFHIT 540
NTTFDFDLCS LDKTTVRKLQ SYLETSGTS 569 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:2000096; P:positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0007379; P:segment specification; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR005033; YEATS. 
Pfam
 PF03366; YEATS 
SMART
  
PROSITE
 PS51037; YEATS 
PRINTS