| Tag | Content |
|---|
| CPLM ID | CPLM-022780 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Multidrug resistance-associated protein 5 |
Protein Synonyms/Alias | ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; SMRP |
Gene Name | Abcc5 |
Gene Synonyms/Alias | Abcc5a; Mrp5 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 383 | AFSQCVQKIREEERR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as a multispecific organic anion pump which can transport nucleotide analogs (By similarity). |
Sequence Annotation | DOMAIN 179 459 ABC transmembrane type-1 1.
DOMAIN 562 783 ABC transporter 1.
DOMAIN 858 1154 ABC transmembrane type-1 2.
DOMAIN 1192 1426 ABC transporter 2.
NP_BIND 595 602 ATP 1 (Potential).
NP_BIND 1226 1233 ATP 2 (Potential).
MOD_RES 43 43 Phosphoserine.
MOD_RES 509 509 Phosphoserine.
MOD_RES 513 513 Phosphothreonine.
CARBOHYD 494 494 N-linked (GlcNAc...) (Potential).
CARBOHYD 636 636 N-linked (GlcNAc...) (Potential).
CARBOHYD 684 684 N-linked (GlcNAc...) (Potential).
CARBOHYD 889 889 N-linked (GlcNAc...) (Potential).
CARBOHYD 896 896 N-linked (GlcNAc...) (Potential).
CARBOHYD 1043 1043 N-linked (GlcNAc...) (Potential).
CARBOHYD 1328 1328 N-linked (GlcNAc...) (Potential).
CARBOHYD 1416 1416 N-linked (GlcNAc...) (Potential). |
Keyword | ATP-binding; Complete proteome; Direct protein sequencing; Glycoprotein; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1436 AA |
Protein Sequence | MKDIDMGKEY IIPSPGYRSD RDRSAVPGQH RDPEEPRFRR TRSLECQDAL ETAARVEGLS 60
LDISVHSHLQ ILDEEHSKGK YHHGLSVLKP FRTTTKHQHP VDNAGLFSYM TFSWLSPLAR 120
VVHKKGELLM EDVWPLSKYE SSDVNSRRLE RLWQEELNEV GPDAASLRRV VWIFCRTRLI 180
LSIVCLMITQ LAGFSGPAFV VKHLLEYTQA TESNLQYSLL LVLGLLLTEV VRSWSLALTW 240
ALNYRTGVRL RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG 300
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFVSRLT AYFRRKCVAA TDDRVQKMNE 360
VLTYIKFIKM YAWVKAFSQC VQKIREEERR ILEKAGYFQS ITVGVAPIVV VIASVVTFSV 420
HMTLGFHLTA AQAFTVVTVF NSMTFALKVT PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK 480
NKPASPHIKI EMKNATLAWD SSHSSIQNSP KLTPKMKKDK RATRGKKEKS RQLQHTEHQA 540
VLAEQKGHLL LDSDERPSPE EEEGKQIHTG SLRLQRTLYN IDLEIEEGKL VGICGSVGSG 600
KTSLVSAILG QMTLLEGSIA VSGTFAYVAQ QAWILNATLR DNILFGKEFD EERYNSVLNS 660
CCLRPDLAIL PNSDLTEIGE RGANLSGGQR QRISLARALY SDRSIYILDD PLSALDAHVG 720
NHIFNSAIRK RLKSKTVLFV THQLQYLVDC DEVIFMKEGC ITERGTHEEL MNLNGDYATI 780
FNNLLLGETP PVEINSKKEA TGSQKSQDKG PKPGSVKKEK AVKSEEGQLV QVEEKGQGSV 840
PWSVYWVYIQ AAGGPLAFLV IMVLFMLNVG STAFSTWWLS YWIKQGSGNS TVYQGNRSFV 900
SDSMKDNPFM QYYASIYALS MAVMLILKAI RGVVFVKGTL RASSRLHDEL FRRILRSPMK 960
FFDTTPTGRI LNRFSKDMDE VDVRLPFQAE MFIQNVILVF FCVGMIAGVF PWFLVAVGPL 1020
LILFSLLHIV SRVLIRELKR LDNITQSPFL SHITSSIQGL ATIHAYNKRQ EFLHRYQELL 1080
DDNQAPFFLF TCAMRWLAVR LDLISIALIT TTGLMIVLMH GQIPSAYAGL AISYAVQLTG 1140
LFQFTVRLAS ETEARFTSVE RINHYIKTLS LEAPARIKNK APPHDWPQEG EVTFENAEMR 1200
YRENLPLVLK KVSFTIKPKE KIGIVGRTGS GKSSLGMALF RLVELSGGCI KIDGIRISDI 1260
GLADLRSKLA IIPQEPVLFS GTVRSNLDPF NQYTEDQIWD ALERTHMKEC IAQLPLKLES 1320
EVMENGDNFS VGERQLLCIA RALLRHCKIL ILDEATAAMD TETDLLIQET IREAFADCTM 1380
LTIAHRLHTV LGSDRIMVLA QGQVVEFDTP SVLLSNDSSR FYAMFAAAEN KVAVKG 1436 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. GO:0006200; P:ATP catabolic process; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |