UniProt Accession

 STOM_HUMAN; P27105; B1AM77; Q14087; Q15609; Q5VX96; Q96FK4 

Genbank Protein ID

 X60067; M81635; X85116; X85117; U33931; U33925; U33926; U33927; U33928; U33929; U33930; CR542100; AL359644; AL161784; AL359644; AL161784; AL161784; AL359644; AL161784; AL359644; BC010703; BI603242 

Genbank Nucleotide ID

 CAA42671.1; AAA58432.1; CAA59436.1; CAA59436.1; AAC50296.1; AAC50296.1; AAC50296.1; AAC50296.1; AAC50296.1; AAC50296.1; AAC50296.1; CAG46897.1; CAH70728.1; CAH70728.1; CAH70729.1; CAH70729.1; CAH72706.1; CAH72706.1; CAH72707.1; CAH72707.1; AAH10703.1 

Protein Name

 Erythrocyte band 7 integral membrane protein 

Protein Synonyms/Alias

 Protein 7.2b; Stomatin 

Gene Name

 STOM 

Gene Synonyms/Alias

 BND7; EPB72 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	QRLPDSFKDSPSKGL	ubiquitination	[1]
198	RVEIKDVKLPVQLQR	ubiquitination	[1]
220	ASREARAKVIAAEGE	ubiquitination	[2]
235	MNASRALKEASMVIT	ubiquitination	[2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Thought to regulate cation conductance. May regulate ASIC2 and ASIC3 gating (By similarity). 

Sequence Annotation

 REGION 265 273 Required for homooligomerization.
 REGION 267 269 Required for lipid raft association.
 REGION 273 287 Interaction with LANCL1.
 MOD_RES 10 10 Phosphoserine; by PKA.
 MOD_RES 161 161 Phosphoserine (By similarity).
 MOD_RES 244 244 Phosphoserine.
 LIPID 30 30 S-palmitoyl cysteine.
 LIPID 87 87 S-palmitoyl cysteine; partial.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Direct protein sequencing; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005856; C:cytoskeleton; IDA:UniProtKB.
 GO:0070062; C:extracellular vesicular exosome; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0045121; C:membrane raft; IDA:UniProtKB.
 GO:0051260; P:protein homooligomerization; IDA:UniProtKB. 

Interpro

 IPR001107; Band_7.
 IPR018080; Band_7/stomatin-like_CS.
 IPR001972; Stomatin. 

Pfam

 PF01145; Band_7 

SMART

 SM00244; PHB 

PROSITE

 PS01270; BAND_7 

PRINTS

 PR00721; STOMATIN.