Tag | Content |
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CPLM ID | CPLM-004750 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial |
Protein Synonyms/Alias | NADH-ubiquinone oxidoreductase 24 kDa subunit |
Gene Name | Ndufv2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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158 | LQRKLGIKVGETTPD | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). |
Sequence Annotation | METAL 134 134 Iron-sulfur (2Fe-2S) (Potential). METAL 139 139 Iron-sulfur (2Fe-2S) (Potential). METAL 175 175 Iron-sulfur (2Fe-2S) (Potential). METAL 179 179 Iron-sulfur (2Fe-2S) (Potential). MOD_RES 192 192 Phosphotyrosine; by SRC (By similarity). |
Keyword | 2Fe-2S; Complete proteome; Direct protein sequencing; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Respiratory chain; Transit peptide; Transport; Ubiquinone. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 248 AA |
Protein Sequence | MFSLALRARA SGLTAQWGRH ARNLHKTAVQ NGAGGALFVH RDTPENNPDT PFDFTPENYE 60 RIEAIVRNYP EGHRAAAVLP VLDLAQRQNG WLPISAMNKV AEVLQVPPMR VYEVATFYTM 120 YNRKPVGKYH IQVCTTTPCM LRDSDSILET LQRKLGIKVG ETTPDKLFTL IEVECLGACV 180 NAPMVQINDD YYEDLTPKDI EEIIDELRAG KVPKPGPRSG RFCCEPAGGL TSLTEPPKGP 240 GFGVQAGL 248 |
Gene Ontology | GO:0005747; C:mitochondrial respiratory chain complex I; IBA:RefGenome. GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IBA:RefGenome. GO:0048738; P:cardiac muscle tissue development; IEA:Compara. GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IBA:RefGenome. GO:0007399; P:nervous system development; IEA:Compara. |
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