CPLM-012141

Genbank Nucleotide ID

Calcium/calmodulin-dependent protein kinase type II subunit gamma

Protein Synonyms/Alias

CaM kinase II subunit gamma; CaMK-II subunit gamma

CAMK; CAMK-II; CAMKG

Homo sapiens (Human)

Position	Peptide	Type	References
227	HKLYQQIKAGAYDFP	ubiquitination	[1]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow- twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.

DOMAIN 14 272 Protein kinase.
NP_BIND 20 28 ATP (By similarity).
REGION 283 292 Autoinhibitory domain.
REGION 291 301 Calmodulin-binding (By similarity).
REGION 294 316 Calmodulin-binding.
ACT_SITE 136 136 Proton acceptor (By similarity).
BINDING 43 43 ATP (By similarity).
MOD_RES 235 235 Phosphoserine (By similarity).
MOD_RES 287 287 Phosphothreonine; by autocatalysis.
MOD_RES 306 306 Phosphothreonine; by autocatalysis (By
MOD_RES 307 307 Phosphothreonine; by autocatalysis
MOD_RES 311 311 Phosphoserine.
MOD_RES 349 349 Phosphoserine.
MOD_RES 352 352 Phosphoserine.
MOD_RES 419 419 Phosphoserine.

3D-structure; Alternative splicing; ATP-binding; Calmodulin-binding; Complete proteome; Developmental protein; Differentiation; Kinase; Membrane; Neurogenesis; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Sarcoplasmic reticulum; Serine/threonine-protein kinase; Transferase.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005954; C:calcium- and calmodulin-dependent protein kinase complex; TAS:UniProtKB.
GO:0005829; C:cytosol; TAS:Reactome.
GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; NAS:UniProtKB.
GO:0004723; F:calcium-dependent protein serine/threonine phosphatase activity; NAS:UniProtKB.
GO:0005516; F:calmodulin binding; NAS:UniProtKB.
GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
GO:0006816; P:calcium ion transport; IEA:Compara.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Compara.
GO:0030073; P:insulin secretion; NAS:UniProtKB.
GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
GO:0046777; P:protein autophosphorylation; IEA:Compara.
GO:0006468; P:protein phosphorylation; NAS:UniProtKB.
GO:0051924; P:regulation of calcium ion transport; TAS:UniProtKB.
GO:0014733; P:regulation of skeletal muscle adaptation; TAS:UniProtKB.
GO:0007268; P:synaptic transmission; TAS:Reactome.

IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR013543; Ca/CaM-dep_prot_kinase-assoc.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.

PF08332; CaMKII_AD
PF00069; Pkinase

PS00107; PROTEIN_KINASE_ATP
PS50011; PROTEIN_KINASE_DOM
PS00108; PROTEIN_KINASE_ST