| Tag | Content |
|---|
| CPLM ID | CPLM-003066 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tryptophan synthase alpha chain |
Protein Synonyms/Alias | |
Gene Name | trpA |
Gene Synonyms/Alias | b1260; JW1252 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 12 | ESLFAQLKERKEGAF | acetylation | [1] | | 15 | FAQLKERKEGAFVPF | acetylation | [1] | | 199 | PLNHLVAKLKEYNAA | acetylation | [1] | | 201 | NHLVAKLKEYNAAPP | acetylation | [1] | | 239 | ISGSAIVKIIEQHIN | acetylation | [1] | | 250 | QHINEPEKMLAALKV | acetylation | [1] | | 256 | EKMLAALKVFVQPMK | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate. |
Sequence Annotation | ACT_SITE 49 49 Proton acceptor (By similarity).
ACT_SITE 60 60 Proton acceptor (By similarity). |
Keyword | 3D-structure; Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; Direct protein sequencing; Lyase; Reference proteome; Tryptophan biosynthesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 268 AA |
Protein Sequence | MERYESLFAQ LKERKEGAFV PFVTLGDPGI EQSLKIIDTL IEAGADALEL GIPFSDPLAD 60
GPTIQNATLR AFAAGVTPAQ CFEMLALIRQ KHPTIPIGLL MYANLVFNKG IDEFYAQCEK 120
VGVDSVLVAD VPVEESAPFR QAALRHNVAP IFICPPNADD DLLRQIASYG RGYTYLLSRA 180
GVTGAENRAA LPLNHLVAKL KEYNAAPPLQ GFGISAPDQV KAAIDAGAAG AISGSAIVKI 240
IEQHINEPEK MLAALKVFVQ PMKAATRS 268 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |