UniProt Accession

 GNAQ_MOUSE; P21279; Q6PFF5 

Genbank Protein ID

 M55412; BC057583 

Genbank Nucleotide ID

 AAA63306.1; AAH57583.1 

Protein Name

 Guanine nucleotide-binding protein G(q) subunit alpha 

Protein Synonyms/Alias

 Guanine nucleotide-binding protein alpha-q 

Gene Name

 Gnaq 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
98	IRAMDTLKIPYKYEH	ubiquitination	[1]
102	DTLKIPYKYEHNKAH	ubiquitination	[1]
107	PYKYEHNKAHAQLVR	ubiquitination	[1]
120	VREVDVEKVSAFENP	ubiquitination	[1]
158	YQLSDSTKYYLNDLD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). 

Sequence Annotation

 NP_BIND 46 53 GTP (By similarity).
 NP_BIND 180 186 GTP (By similarity).
 NP_BIND 205 209 GTP (By similarity).
 NP_BIND 274 277 GTP (By similarity).
 METAL 53 53 Magnesium (By similarity).
 METAL 186 186 Magnesium (By similarity).
 BINDING 331 331 GTP; via amide nitrogen (By similarity).
 LIPID 9 9 S-palmitoyl cysteine.
 LIPID 10 10 S-palmitoyl cysteine.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Nucleus; Palmitate; Reference proteome; Transducer. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 359 AA 

Protein Sequence

Gene Ontology

 GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0001664; F:G-protein coupled receptor binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0005096; F:GTPase activator activity; IBA:RefGenome.
 GO:0003924; F:GTPase activity; IBA:RefGenome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IDA:MGI.
 GO:0048066; P:developmental pigmentation; IMP:MGI.
 GO:0042733; P:embryonic digit morphogenesis; IGI:MGI.
 GO:0021884; P:forebrain neuron development; IMP:MGI.
 GO:0007215; P:glutamate receptor signaling pathway; IMP:MGI.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0042711; P:maternal behavior; IMP:MGI.
 GO:0006469; P:negative regulation of protein kinase activity; IEA:Compara.
 GO:0016322; P:neuron remodeling; IMP:MGI.
 GO:0060158; P:phospholipase C-activating dopamine receptor signaling pathway; IGI:MGI.
 GO:0009791; P:post-embryonic development; IMP:MGI.
 GO:0050821; P:protein stabilization; IEA:Compara.
 GO:0001508; P:regulation of action potential; IMP:MGI.
 GO:0035412; P:regulation of catenin import into nucleus; IEA:Compara.
 GO:0045634; P:regulation of melanocyte differentiation; IMP:MGI.
 GO:0001501; P:skeletal system development; IMP:MGI. 

Interpro

 IPR000654; Gprotein_alpha_Q.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00503; G-alpha 

SMART

 SM00275; G_alpha 

PROSITE

  

PRINTS

 PR00318; GPROTEINA.
 PR00442; GPROTEINAQ.