UniProt Accession

 SYT4_HUMAN; Q9H2B2; Q9P2K4 

Genbank Protein ID

 AF299075; AB037763; BC036538 

Genbank Nucleotide ID

 AAG37229.1; BAA92580.1; AAH36538.1 

Protein Name

 Synaptotagmin-4 

Protein Synonyms/Alias

 Synaptotagmin IV; SytIV 

Gene Name

 SYT4 

Gene Synonyms/Alias

 KIAA1342 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
58	YKFVHVLKGVDIYPE	ubiquitination	[1]
111	NFPKTNLKPGSPSDL	ubiquitination	[1]
316	LKARHLPKSDVSGLS	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. 

Sequence Annotation

 DOMAIN 155 258 C2 1.
 DOMAIN 289 392 C2 2.
 REGION 147 297 Phospholipid binding (Probable).
 METAL 184 184 Calcium 1 (By similarity).
 METAL 184 184 Calcium 2 (By similarity).
 METAL 191 191 Calcium 1 (By similarity).
 METAL 245 245 Calcium 1; via carbonyl oxygen (By
 METAL 246 246 Calcium 1 (By similarity).
 METAL 246 246 Calcium 2 (By similarity).
 METAL 246 246 Calcium 3 (By similarity).
 METAL 249 249 Calcium 3 (By similarity).
 METAL 252 252 Calcium 2 (By similarity).
 METAL 252 252 Calcium 3 (By similarity).  

Keyword

 3D-structure; Calcium; Cell junction; Complete proteome; Cytoplasmic vesicle; Membrane; Metal-binding; Polymorphism; Reference proteome; Repeat; Synapse; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 425 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:Compara.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0007269; P:neurotransmitter secretion; IEA:Compara. 

Interpro

 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR001565; Synaptotagmin. 

Pfam

 PF00168; C2 

SMART

 SM00239; C2 

PROSITE

 PS50004; C2 

PRINTS

 PR00399; SYNAPTOTAGMN.