UniProt Accession

 GPM6A_RAT; Q812E9 

Genbank Protein ID

 AB089242; CH473995; BC088862; DV216104 

Genbank Nucleotide ID

 BAC56699.1; EDL78956.1; AAH88862.1 

Protein Name

 Neuronal membrane glycoprotein M6-a 

Protein Synonyms/Alias

 M6a 

Gene Name

 Gpm6a 

Gene Synonyms/Alias

 m6a 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
250	KDACRMQKYEDIKSK	acetylation	[1]
250	KDACRMQKYEDIKSK	ubiquitination	[2]
255	MQKYEDIKSKEEQEL	ubiquitination	[2]
257	KYEDIKSKEEQELHD	acetylation	[1]
257	KYEDIKSKEEQELHD	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells (By similarity). Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. 

Sequence Annotation

 CARBOHYD 164 164 N-linked (GlcNAc...) (Potential).
 CARBOHYD 208 208 N-linked (GlcNAc...) (Potential).
 DISULFID 174 192  

Keyword

 Alternative splicing; Cell membrane; Cell projection; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Neurogenesis; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 278 AA 

Protein Sequence

Gene Ontology

 GO:0044295; C:axonal growth cone; ISS:UniProtKB.
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
 GO:0030175; C:filopodium; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043025; C:neuronal cell body; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005262; F:calcium channel activity; IDA:RGD.
 GO:0003407; P:neural retina development; ISS:UniProtKB.
 GO:0001764; P:neuron migration; ISS:UniProtKB.
 GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
 GO:0051491; P:positive regulation of filopodium assembly; IDA:UniProtKB.
 GO:0048863; P:stem cell differentiation; ISS:UniProtKB.
 GO:0007416; P:synapse assembly; IDA:UniProtKB. 

Interpro

 IPR001614; Myelin_PLP.
 IPR018237; Myelin_PLP_CS. 

Pfam

 PF01275; Myelin_PLP 

SMART

 SM00002; PLP 

PROSITE

 PS00575; MYELIN_PLP_1
 PS01004; MYELIN_PLP_2 

PRINTS

 PR00214; MYELINPLP.