CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000194
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Flotillin-1 
Protein Synonyms/Alias
  
Gene Name
 Flot1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
78VKIQGQNKEMLAAACubiquitination[1]
392SGTMGAAKVTGEVLDubiquitination[1]
423ISQVNHNKPLRTA**ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. 
Sequence Annotation
 MOD_RES 19 19 Phosphoserine (By similarity).
 MOD_RES 385 385 Phosphoserine (By similarity).  
Keyword
 Cell membrane; Complete proteome; Direct protein sequencing; Endosome; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 428 AA 
Protein Sequence
MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV KSEKVYTRHG 60
VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA LETLEGHQRA IMAHMTVEEI 120
YKDRQKFSEQ VFKVASSDLV NMGISVVSYT LKDIHDDQDY LHSLGKARTA QVQKDARIGE 180
AEAKRDAGIR EAKAKQEKVS AQCLSEIEMA KAQRDYELKK ATYDIEVNTR RAQADLAYQL 240
QVAKTKQQIE EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYRLERLAEA 300
EKAQLIMQAE AEAESVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQMYQE AAQLDMLLEK 360
LPQVAEEISG PLTSANKITL VSSGSGTMGA AKVTGEVLDI LSRLPESVER LTGVSISQVN 420
HNKPLRTA 428 
Gene Ontology
 GO:0034451; C:centriolar satellite; IEA:Compara.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0016600; C:flotillin complex; IDA:BHF-UCL.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0042383; C:sarcolemma; IDA:MGI.
 GO:0008180; C:signalosome; IEA:Compara.
 GO:0007409; P:axonogenesis; IMP:MGI.
 GO:0072659; P:protein localization to plasma membrane; IMP:MGI.
 GO:0035023; P:regulation of Rho protein signal transduction; IMP:MGI. 
Interpro
 IPR001107; Band_7. 
Pfam
 PF01145; Band_7 
SMART
 SM00244; PHB 
PROSITE
  
PRINTS