UniProt Accession

 SEH1_HUMAN; Q96EE3; A8K5B1; Q8NFU6; Q96MH3; Q9C069 

Genbank Protein ID

 AF255625; AF431970; AF514996; AF136976; AK056940; AK291226; BC012430 

Genbank Nucleotide ID

 AAM21169.1; AAM44214.1; AAM76707.1; AAG49437.1; BAB71317.1; BAF83915.1; AAH12430.1 

Protein Name

 Nucleoporin SEH1 

Protein Synonyms/Alias

 Nup107-160 subcomplex subunit SEH1; SEC13-like protein 

Gene Name

 SEH1L 

Gene Synonyms/Alias

 SEC13L; SEH1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	RSIAADHKDLIHDVS	ubiquitination	[1, 2]
37	CSSDQSVKVWDKSES	ubiquitination	[1]
41	QSVKVWDKSESGDWH	ubiquitination	[1]
96	IVGESNDKLRGQSHW	ubiquitination	[1, 2]
120	RTSVTDVKFAPKHMG	ubiquitination	[1]
124	TDVKFAPKHMGLMLA	ubiquitination	[1]
196	SSPNAMAKVQIFEYN	ubiquitination	[1]
251	DVRIFTLKPVRKELT	ubiquitination	[1]
306	DGCVRLWKANYMDNW	ubiquitination	[1, 2]
314	ANYMDNWKCTGILKG	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. 

Sequence Annotation

 REPEAT 10 49 WD 1.
 REPEAT 55 96 WD 2.
 REPEAT 111 152 WD 3.
 REPEAT 160 210 WD 4.
 REPEAT 217 258 WD 5.
 REPEAT 276 315 WD 6.  

Keyword

 Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Complete proteome; Kinetochore; Mitosis; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Translocation; Transport; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0031080; C:nuclear pore outer ring; IDA:UniProtKB.
 GO:0051315; P:attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation; IMP:UniProtKB.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.
 GO:0015758; P:glucose transport; TAS:Reactome.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0007080; P:mitotic metaphase plate congression; IMP:UniProtKB.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0006999; P:nuclear pore organization; IMP:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0010827; P:regulation of glucose transport; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome.
 GO:0022415; P:viral reproductive process; TAS:Reactome. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.