CPLM-010421

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-010421

UniProt Accession

BT3A2_HUMAN; P78410; B4DRT7; B4E103; F5H791; F8W6E0; O00477; O15338; O75658; Q76PA0; Q9BU81; Q9NR44

Genbank Protein ID

U90546; U90144; U97499; U97498; AF257505; AK299417; AK303600; AL021917; BC002832; BC020214

Genbank Nucleotide ID

AAB53424.1; AAC02652.1; AAC02655.1; AAC02655.1; AAF76140.1; BAG61399.1; BAG64615.1; CAA17277.2; AAH02832.3; AAH20214.3

Protein Name

Butyrophilin subfamily 3 member A2

Protein Synonyms/Alias

Gene Name

BTN3A2

Gene Synonyms/Alias

BT3.2; BTF3; BTF4

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
231	NSLLGLEKTASISIA	ubiquitination	[1]
313	ESLQEELKRKKIQYL	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells.

Sequence Annotation

DOMAIN 30 139 Ig-like V-type.
MOD_RES 282 282 Phosphoserine.
MOD_RES 286 286 Phosphoserine.
CARBOHYD 115 115 N-linked (GlcNAc...) (Potential).
DISULFID 52 126
DISULFID 166 220

Keyword

3D-structure; Adaptive immunity; Alternative splicing; Cell membrane; Coiled coil; Complete proteome; Disulfide bond; Glycoprotein; Immunity; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

334 AA

Protein Sequence

MKMASSLAFL LLNFHVSLLL VQLLTPCSAQ FSVLGPSGPI LAMVGEDADL PCHLFPTMSA 60
ETMELKWVSS SLRQVVNVYA DGKEVEDRQS APYRGRTSIL RDGITAGKAA LRIHNVTASD 120
SGKYLCYFQD GDFYEKALVE LKVAALGSNL HVEVKGYEDG GIHLECRSTG WYPQPQIQWS 180
NAKGENIPAV EAPVVADGVG LYEVAASVIM RGGSGEGVSC IIRNSLLGLE KTASISIADP 240
FFRSAQPWIA ALAGTLPILL LLLAGASYFL WRQQKEITAL SSEIESEQEM KEMGYAATER 300
EISLRESLQE ELKRKKIQYL TRGEESSSDT NKSA 334

Gene Ontology

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0072643; P:interferon-gamma secretion; IMP:UniProtKB.
GO:0002456; P:T cell mediated immunity; IMP:UniProtKB.

Interpro

IPR007110; Ig-like_dom.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR013106; Ig_V-set.

Pfam

PF07686; V-set

SMART

SM00409; IG

PROSITE

PS50835; IG_LIKE

PRINTS