UniProt Accession

 TEFM_HUMAN; Q96QE5; E1P655; Q6GPG5; Q6PJ19; Q96H04; Q9H5Z9 

Genbank Protein ID

 AJ314645; AK026382; CH471147; CH471147; BC009025; BC073169; CR457360 

Genbank Nucleotide ID

 CAC44534.1; BAB15468.1; EAW80290.1; EAW80292.1; AAH09025.2; AAH73169.1; CAG33641.1 

Protein Name

 Transcription elongation factor, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 TEFM 

Gene Synonyms/Alias

 C17orf42 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
124	NVPLFKYKSTVQVCN	ubiquitination	[1, 2]
137	CNSILCPKTGREKRK	ubiquitination	[1, 2]
283	MNRNAVGKHFELMIG	ubiquitination	[1, 2]
310	FLFDSILKADPRVFF	ubiquitination	[1, 2]
321	RVFFPSDKIVHYRQM	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery. 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Mitochondrion; Mitochondrion nucleoid; Polymorphism; Reference proteome; Transcription; Transcription regulation; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0042645; C:mitochondrial nucleoid; IDA:UniProtKB.
 GO:0030529; C:ribonucleoprotein complex; IDA:UniProtKB.
 GO:0030337; F:DNA polymerase processivity factor activity; IDA:UniProtKB.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0006119; P:oxidative phosphorylation; IMP:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006390; P:transcription from mitochondrial promoter; IMP:UniProtKB. 

Interpro

 IPR012337; RNaseH-like_dom.
 IPR023097; Tex_RuvX-like_dom. 

Pfam

  

SMART

  

PROSITE

  

PRINTS