CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015063
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Uracil nucleotide/cysteinyl leukotriene receptor 
Protein Synonyms/Alias
 UDP/CysLT receptor; G-protein coupled receptor 17 
Gene Name
 Gpr17 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
327PPPSFEGKTNESSLSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia (By similarity). 
Sequence Annotation
 CARBOHYD 14 14 N-linked (GlcNAc...) (Potential).
 CARBOHYD 176 176 N-linked (GlcNAc...) (Potential).
 DISULFID 104 181 By similarity.  
Keyword
 Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 339 AA 
Protein Sequence
MNGLEAALPS LTDNSSLAYS EQCGQETPLE NMLFACFYLL DFILAFVGNA LALWLFIWDH 60
KSGTPANVFL MHLAVADLSC VLVLPTRLVY HFSGNHWPFG EIPCRLTGFL FYLNMYASIY 120
FLTCISADRF LAIVHPVKSL KLRRPLYAHL ACAFLWIVVA VAMAPLLVSP QTVQTNHTVV 180
CLQLYREKAS HHALASLAVA FTFPFITTVT CYLLIIRSLR QGPRIEKHLK NKAVRMIAMV 240
LAIFLICFVP YHIHRSVYVL HYRGGGTSCA AQRALALGNR ITSCLTSLNG ALDPVMYFFV 300
AEKFRHALCN LLCSKRLTGP PPSFEGKTNE SSLSARSEL 339 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0045028; F:G-protein coupled purinergic nucleotide receptor activity; IEA:InterPro. 
Interpro
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR002286; purinergic_P2Y_rcpt. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR00237; GPCRRHODOPSN.
 PR01157; P2YPURNOCPTR.