CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023180
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 YEATS domain-containing protein 2 
Protein Synonyms/Alias
  
Gene Name
 YEATS2 
Gene Synonyms/Alias
 KIAA1197 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
25VSVALPNKRHKAIENubiquitination[1]
308IDIIHNLKLDRTYTGubiquitination[1]
644EGIAQSAKVQPSKVVubiquitination[2]
649SAKVQPSKVVGVPVGubiquitination[1]
685KASSSVSKAVGPKQVubiquitination[1]
719QPVQTLTKAQVTAAGubiquitination[1, 3]
766LYLTTNSKNPSGKGKubiquitination[1]
773KNPSGKGKLLLIPQGubiquitination[1, 4]
923GGQASLMKISDSTLKubiquitination[1]
930KISDSTLKTVPATSQubiquitination[1]
940PATSQLSKPGTTMLRubiquitination[1]
1084VQSFSTSKPPAILPVubiquitination[1]
1159QLLTAVVKKIPLITAubiquitination[1]
1160LLTAVVKKIPLITAKubiquitination[1]
1276SADNLCRKLEDLQQFubiquitination[1]
1285EDLQQFQKREPENEEubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
 Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. 
Sequence Annotation
 DOMAIN 207 317 YEATS.
 MOD_RES 118 118 Phosphoserine.
 MOD_RES 447 447 Phosphoserine.
 MOD_RES 463 463 Phosphoserine.
 MOD_RES 465 465 Phosphoserine.
 MOD_RES 471 471 Phosphoserine.
 MOD_RES 473 473 Phosphoserine.
 MOD_RES 536 536 Phosphoserine.
 MOD_RES 575 575 Phosphoserine.
 MOD_RES 627 627 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1422 AA 
Protein Sequence
MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ENSARDAAVQ KIETIIKEQF ALEMKNKEHE 60
IEVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGSK TCDTMVFNHP AIKKFLESPS 120
RSSSPANQRA ETPSANHSES DSLSQHNDFL SDKDNNSNMD IEERLSNNME QRPSRNTGRD 180
TSRITGSHKT EQRNADLTDE TSRLFVKKTI VVGNVSKYIP PDKREENDQS THKWMVYVRG 240
SRREPSINHF VKKVWFFLHP SYKPNDLVEV REPPFHLTRR GWGEFPVRVQ VHFKDSQNKR 300
IDIIHNLKLD RTYTGLQTLG AETVVDVELH RHSLGEDCIY PQSSESDISD APPSLPLTIP 360
APVKASSPIK QSHEPVPDTS VEKGFPASTE AERHTPFYAL PSSLERTPTK MTTSQKVTFC 420
SHGNSAFQPI ASSCKIVPQS QVPNPESPGK SFQPITMSCK IVSGSPISTP SPSPLPRTPT 480
STPVHVKQGT AGSVINNPYV IMDKQPGQVI GATTPSTGSP TNKISTASQV SQGTGSPVPK 540
IHGSSFVTST VKQEDSLFAS MPPLCPIGSH PKVQSPKPIT GGLGAFTKVI IKQEPGEAPH 600
VPATGAASQS PLPQYVTVKG GHMIAVSPQK QVITPGEGIA QSAKVQPSKV VGVPVGSALP 660
STVKQAVAIS GGQILVAKAS SSVSKAVGPK QVVTQGVAKA IVSGGGGTIV AQPVQTLTKA 720
QVTAAGPQKS GSQGSVMATL QLPATNLANL ANLPPGTKLY LTTNSKNPSG KGKLLLIPQG 780
AILRATNNAN LQSGSAASGG SGAGGGGGGG GGGGSGSGGG GSTGGGGGTA GGGTQSTAGP 840
GGISQHLTYT SYILKQTPQG TFLVGQPSPQ TSGKQLTTGS VVQGTLGVST SSAQGQQTLK 900
VISGQKTTLF TQAAHGGQAS LMKISDSTLK TVPATSQLSK PGTTMLRVAG GVITTATSPA 960
VALSANGPAQ QSEGMAPVSS STVSSVTKTS GQQQVCVSQA TVGTCKAATP TVVSATSLVP 1020
TPNPISGKAT VSGLLKIHSS QSSPQQAVLT IPSQLKPLSV NTSGGVQTIL MPVNKVVQSF 1080
STSKPPAILP VAAPTPVVPS SAPAAVAKVK TEPETPGPSC LSQEGQTAVK TEESSELGNY 1140
VIKIDHLETI QQLLTAVVKK IPLITAKSED ASCFSAKSVE QYYGWNIGKR RAAEWQRAMT 1200
MRKVLQEILE KNPRFHHLTP LKTKHIAHWC RCHGYTPPDP ESLRNDGDSI EDVLTQIDSE 1260
PECPSSFSSA DNLCRKLEDL QQFQKREPEN EEEVDILSLS EPVKINIKKE QEEKQEEVKF 1320
YLPPTPGSEF IGDVTQKIGI TLQPVALHRN VYASVVEDMI LKATEQLVND ILRQALAVGY 1380
QTASHNRIPK EITVSNIHQA ICNIPFLDFL TNKHMGILNE DQ 1422 
Gene Ontology
 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:BHF-UCL.
 GO:0072686; C:mitotic spindle; IEA:Compara.
 GO:0043966; P:histone H3 acetylation; IDA:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL. 
Interpro
 IPR005033; YEATS. 
Pfam
 PF03366; YEATS 
SMART
  
PROSITE
 PS51037; YEATS 
PRINTS