| Tag | Content |
|---|
| CPLM ID | CPLM-023888 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NEDD8 ultimate buster 1 |
Protein Synonyms/Alias | Negative regulator of ubiquitin-like proteins 1; Renal carcinoma antigen NY-REN-18 |
Gene Name | NUB1 |
Gene Synonyms/Alias | NYREN18 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 159 | KAMVLELKQSEEDAR | ubiquitination | [1] | | 167 | QSEEDARKNFQLEEE | ubiquitination | [1] | | 371 | NKARQLFKELYIDPS | ubiquitination | [1] | | 379 | ELYIDPSKVDNLLQL | ubiquitination | [1] | | 440 | LENIRFLKGMGYSTH | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. |
Sequence Annotation | DOMAIN 374 413 UBA 1.
DOMAIN 424 470 UBA 2.
DOMAIN 489 529 UBA 3.
REGION 427 474 NEDD8-binding 1.
REGION 550 598 NEDD8-binding 2.
MOTIF 414 431 Nuclear localization signal (Probable). |
Keyword | 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Nucleus; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 615 AA |
Protein Sequence | MAQKKYLQAK LTQFLREDRI QLWKPPYTDE NKKVGLALKD LAKQYSDRLE CCENEVEKVI 60
EEIRCKAIER GTGNDNYRTT GIATIEVFLP PRLKKDRKNL LETRLHITGR ELRSKIAETF 120
GLQENYIKIV INKKQLQLGK TLEEQGVAHN VKAMVLELKQ SEEDARKNFQ LEEEEQNEAK 180
LKEKQIQRTK RGLEILAKRA AETVVDPEMT PYLDIANQTG RSIRIPPSER KALMLAMGYH 240
EKGRAFLKRK EYGIALPCLL DADKYFCECC RELLDTVDNY AVLQLDIVWC YFRLEQLECL 300
DDAEKKLNLA QKCFKNCYGE NHQRLVHIKG NCGKEKVLFL RLYLLQGIRN YHSGNDVEAY 360
EYLNKARQLF KELYIDPSKV DNLLQLGFTA QEARLGLRAC DGNVDHAATH ITNRREELAQ 420
IRKEEKEKKR RRLENIRFLK GMGYSTHAAQ QILLSNPQMW WLNDSNPETD NRQESPSQEN 480
IDRLVYMGFD ALVAEAALRV FRGNVQLAAQ TLAHNGGSLP PELPLSPEDS LSPPATSPSD 540
SAGTSSASTD EDMETEAVNE ILEDIPEHEE DYLDSTLEDE EIIIAEYLSY VENRKSATKK 600
N 601 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB. GO:0016567; P:protein ubiquitination; IMP:UniProtKB. GO:0034341; P:response to interferon-gamma; IEP:UniProtKB. GO:0034612; P:response to tumor necrosis factor; IEP:UniProtKB. GO:0006511; P:ubiquitin-dependent protein catabolic process; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |