UniProt Accession

 CSN8_PONAB; Q5RF54 

Genbank Protein ID

 CR857307 

Genbank Nucleotide ID

 CAH89603.1 

Protein Name

 COP9 signalosome complex subunit 8 

Protein Synonyms/Alias

 Signalosome subunit 8 

Gene Name

 COPS8 

Gene Synonyms/Alias

 CSN8 

Created Date

 July 27, 2013 

Organism

 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 

NCBI Taxa ID

 9601 

Lysine Modification

Position	Peptide	Type	References
166	TRMVLPRKPVAGALD	ubiquitination	[1]
178	ALDVSFNKFIPLSEP	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). 

Sequence Annotation

 DOMAIN 68 151 PCI.
 MOD_RES 175 175 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Signalosome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 209 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008180; C:signalosome; IEA:UniProtKB-KW.
 GO:0010388; P:cullin deneddylation; IEA:Compara. 

Interpro

  

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SMART

  

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PRINTS