| Tag | Content |
|---|
| CPLM ID | CPLM-019905 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable cytosolic iron-sulfur protein assembly protein CIAO1 |
Protein Synonyms/Alias | WD repeat-containing protein 39 |
Gene Name | Ciao1 |
Gene Synonyms/Alias | Wdr39 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 2 | ******MKDSLVLQS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity). |
Sequence Annotation | REPEAT 14 53 WD 1.
REPEAT 59 98 WD 2.
REPEAT 103 142 WD 3.
REPEAT 148 187 WD 4.
REPEAT 192 231 WD 5.
REPEAT 250 289 WD 6.
REPEAT 301 339 WD 7. |
Keyword | Chromosome partition; Complete proteome; Reference proteome; Repeat; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 339 AA |
Protein Sequence | MKDSLVLQSR VPAHPDSRCW FLAWNPSGTL LASCGGDRKI RIWGTEGDSW ICKSVLSEGH 60
QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL 120
ATCSRDKSVW VWEVDEEDEY ECVSVLSSHT QDVKHVVWHP SQELLASASY DDTVKLYQEE 180
GDDWVCCATL EGHESTVWSI AFDPSGQRLA SCSDDRTVRI WRQYLPGNEQ GVACSGSDPS 240
WKCICTLSGF HTRTIYDVAW CQLTGALATA CGDDAIRVFE EDPGSDPQQP TFSLTAHLRQ 300
AHSQDVNCVA WNPKEPGLLA SCSDDGEVAF WEYHQPAGL 339 |
Gene Ontology | GO:0097361; C:CIA complex; ISS:UniProtKB. GO:0071817; C:MMXD complex; ISS:UniProtKB. GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:MGI. GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW. GO:0016226; P:iron-sulfur cluster assembly; ISS:UniProtKB. GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:MGI. |
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