UniProt Accession

 EMB_HUMAN; Q6PCB8; B7Z6S3 

Genbank Protein ID

 AK300860; CH471123; BC059398 

Genbank Nucleotide ID

 BAH13359.1; EAW54853.1; AAH59398.1 

Protein Name

 Embigin 

Protein Synonyms/Alias

  

Gene Name

 EMB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
105	AVNVTWKKDGEQLEN	ubiquitination	[1]
135	RFTIINSKQMGSYSC	ubiquitination	[1]
157	QRGTFNFKVPELHGK	ubiquitination	[1]
166	PELHGKNKPLISYVG	ubiquitination	[1]
296	KKHSDEGKEFEQIEQ	ubiquitination	[2]
305	FEQIEQLKSDDSNGI	ubiquitination	[2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May function as a regulator of cell/ECM interactions during development and in the homeostasis of normal adult tissues (By similarity). 

Sequence Annotation

 DOMAIN 71 158 Ig-like V-type 1.
 DOMAIN 159 253 Ig-like V-type 2.
 CARBOHYD 54 54 N-linked (GlcNAc...) (Potential).
 CARBOHYD 61 61 N-linked (GlcNAc...) (Potential).
 CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
 CARBOHYD 85 85 N-linked (GlcNAc...) (Potential).
 CARBOHYD 100 100 N-linked (GlcNAc...) (Potential).
 CARBOHYD 189 189 N-linked (GlcNAc...) (Potential).
 CARBOHYD 196 196 N-linked (GlcNAc...) (Potential).
 CARBOHYD 213 213 N-linked (GlcNAc...).
 CARBOHYD 218 218 N-linked (GlcNAc...).
 DISULFID 88 142 By similarity.
 DISULFID 180 237 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0007155; P:cell adhesion; IEA:Compara. 

Interpro

 IPR027114; Embigin.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub. 

Pfam

 PF07679; I-set 

SMART

 SM00409; IG 

PROSITE

 PS50835; IG_LIKE 

PRINTS