UniProt Accession

 G3V2A0_HUMAN; G3V2A0 

Genbank Protein ID

 AL163051 

Genbank Nucleotide ID

  

Protein Name

 Poly(A) polymerase alpha 

Protein Synonyms/Alias

  

Gene Name

 PAPOLA 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
110	LSKAEWSKLFEAPNF	ubiquitination	[1, 2]
120	EAPNFFQKYKHYIVL	ubiquitination	[2]
400	PTPIVGVKRTSSPHK	acetylation	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 475 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:HPA.
 GO:0004652; F:polynucleotide adenylyltransferase activity; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0043631; P:RNA polyadenylation; IEA:Compara. 

Interpro

 IPR011068; NuclTrfase_I_C.
 IPR007012; PolA_pol_cen_dom.
 IPR007010; PolA_pol_RNA-bd_dom. 

Pfam

 PF04928; PAP_central
 PF04926; PAP_RNA-bind 

SMART

  

PROSITE

  

PRINTS