CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044197
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger CCCH domain-containing protein 7A 
Protein Synonyms/Alias
 Zinc finger CCCH-type containing 7A, isoform CRA_b 
Gene Name
 ZC3H7A 
Gene Synonyms/Alias
 hCG_14614 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
85SEEILIPKEIIEKLYubiquitination[1]
90IPKEIIEKLYINRIAubiquitination[1]
124SLNASNCKALYRKSKubiquitination[1]
131KALYRKSKALSDLGRubiquitination[1]
140LSDLGRYKKAYDAVAubiquitination[1]
148KAYDAVAKCSLAVPQubiquitination[1]
169LTQELAQKLGFKIRKubiquitination[1]
186VRAELSLKSVPGDGAubiquitination[1]
195VPGDGATKALNHSVEubiquitination[1]
335FFGSAVTKPSSSVTPubiquitination[1, 2, 3, 4, 5, 6]
362ACQICFVKSGPKLMDubiquitination[5]
366CFVKSGPKLMDFTYHubiquitination[1]
381ANIDHKCKKDILIGRubiquitination[1]
382NIDHKCKKDILIGRIubiquitination[1]
417EGPYYICKDVAAEEEubiquitination[1]
510ACSHPVTKHEFEDNKubiquitination[1]
517KHEFEDNKCLVHILRubiquitination[1]
619GFLNMKIKFVCAQCLubiquitination[1]
636GQVIEPDKNRKYCSAubiquitination[1]
676IRPLPTKKQMPLQFDubiquitination[1]
693NHIASGKKCQYVGNCubiquitination[1, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 733 AA 
Protein Sequence
MSNVSEERRK RQQNIKEGLQ FIQSPLSYPG TQEQYAVYLR ALVRNLFNEG NDVYREHDWN 60
NSISQYTEAL NIADYAKSEE ILIPKEIIEK LYINRIACYS NMGFHDKVLE DCNIVLSLNA 120
SNCKALYRKS KALSDLGRYK KAYDAVAKCS LAVPQDEHVI KLTQELAQKL GFKIRKAYVR 180
AELSLKSVPG DGATKALNHS VEDIEPDLLT PRQEAVPVVS LPAPSFSHEV GSELASVPVM 240
PLTSILPLQV EESALPSAVL ANGGKMPFTM PEAFLDDGDM VLGDELDDLL DSAPETNETV 300
MMNGPGSLFA SENFLGISSQ PRNDFGNFFG SAVTKPSSSV TPRHPLEGTH ELRQACQICF 360
VKSGPKLMDF TYHANIDHKC KKDILIGRIK NVEDKSWKKI RPRPTKTNYE GPYYICKDVA 420
AEEECRYSGH CTFAYCQEEI DVWTLERKGA FSREAFFGGN GKINLTVFKL LQEHLGEFIF 480
LCEKCFDHKP RMISKRNKDN STACSHPVTK HEFEDNKCLV HILRETTVKY SKIRSFHGQC 540
QLDLCRHEVR YGCLREDECF YAHSLVELKV WIMQNETGIS HDAIAQESKR YWQNLEANVP 600
GAQVLGNQIM PGFLNMKIKF VCAQCLRNGQ VIEPDKNRKY CSAKARHSWT KDRRAMRVMS 660
IERKKWMNIR PLPTKKQMPL QFDLCNHIAS GKKCQYVGNC SFAHSPEERE VWTYMKENGI 720
QDMEQFYELW LKS 733 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR011990; TPR-like_helical.
 IPR000571; Znf_CCCH. 
Pfam
  
SMART
  
PROSITE
 PS50103; ZF_C3H1 
PRINTS