UniProt Accession

 PPM1B_MOUSE; P36993 

Genbank Protein ID

 D17411; D17412; D45859; D45860; D45861; U09218; AB007798 

Genbank Nucleotide ID

 BAA04233.1; BAA04234.1; BAA08293.1; BAA08294.1; BAA08295.1; AAB60442.1; BAA84471.1 

Protein Name

 Protein phosphatase 1B 

Protein Synonyms/Alias

 Protein phosphatase 2C isoform beta; PP2C-beta 

Gene Name

 Ppm1b 

Gene Synonyms/Alias

 Pp2c2; Pppm1b 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
90	EDFRAADKSGSALEP	acetylation	[1]
90	EDFRAADKSGSALEP	ubiquitination	[2]
112	GIRTGFLKIDEYMRN	ubiquitination	[2]
314	KRDSELDKHLESRVE	ubiquitination	[2]
326	RVEEIMQKSGEEGMP	ubiquitination	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Enzyme with a broad specificity. 

Sequence Annotation

 METAL 60 60 Manganese 1 (By similarity).
 METAL 60 60 Manganese 2 (By similarity).
 METAL 61 61 Manganese 1; via carbonyl oxygen (By
 METAL 243 243 Manganese 2 (By similarity).
 METAL 286 286 Manganese 2 (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 390 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030145; F:manganese ion binding; IEA:InterPro.
 GO:0004722; F:protein serine/threonine phosphatase activity; IEA:InterPro.
 GO:0006499; P:N-terminal protein myristoylation; IDA:UniProtKB.
 GO:0050687; P:negative regulation of defense response to virus; ISS:UniProtKB.
 GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.
 GO:0032688; P:negative regulation of interferon-beta production; ISS:UniProtKB.
 GO:0042347; P:negative regulation of NF-kappaB import into nucleus; ISS:UniProtKB.
 GO:0006470; P:protein dephosphorylation; IMP:UniProtKB. 

Interpro

 IPR001932; PP2C-like.
 IPR012911; PP2C_C.
 IPR000222; PP2C_Mn2_Asp60_BS.
 IPR015655; Protein_Pase_2C. 

Pfam

 PF00481; PP2C
 PF07830; PP2C_C 

SMART

 SM00331; PP2C_SIG
 SM00332; PP2Cc 

PROSITE

 PS01032; PP2C 

PRINTS