| Tag | Content |
|---|
| CPLM ID | CPLM-021984 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Synembryn-A |
Protein Synonyms/Alias | Protein Ric-8A |
Gene Name | RIC8A |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 415 | ESVPRFIKYTGYGNA | ubiquitination | [1] | | 495 | KLVTMFDKLSRNRVI | ubiquitination | [1] |
|
Reference | [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C. Nat Cell Biol. 2012 Oct;14(10):1089-98. [ PMID: 23000965] |
Functional Description | Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. |
Sequence Annotation | MOD_RES 199 199 Phosphothreonine (By similarity).
MOD_RES 436 436 Phosphoserine.
MOD_RES 441 441 Phosphothreonine.
MOD_RES 502 502 Phosphoserine.
MOD_RES 523 523 Phosphoserine.
MOD_RES 524 524 Phosphoserine.
MOD_RES 528 528 Phosphoserine. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Membrane; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 531 AA |
Protein Sequence | MEPRAVAEAV ETGEEDVIME ALRSYNQEHS QSFTFDDAQQ EDRKRLAELL VSVLEQGLPP 60
SHRVIWLQSV RILSRDRNCL DPFTSRQSLQ ALACYADISV SEGSVPESAD MDVVLESLKC 120
LCNLVLSSPV AQMLAAEARL VVKLTERVGL YRERSFPHDV QFFDLRLLFL LTALRTDVRQ 180
QLFQELKGVR LLTDTLELTL GVTPEGNPPP TLLPSQETER AMEILKVLFN ITLDSIKGEV 240
DEEDAALYRH LGTLLRHCVM IATAGDRTEE FHGHAVNLLG NLPLKCLDVL LTLEPHGDST 300
EFMGVNMDVI RALLIFLEKR LHKTHRLKES VAPVLSVLTE CARMHRPARK FLKAQGWPPP 360
QVLPPLRDVR TRPEVGEMLR NKLVRLMTHL DTDVKRVAAE FLFVLCSESV PRFIKYTGYG 420
NAAGLLAARG LMAGGRPEGQ YSEDEDTDTD EYKEAKASIN PVTGRVEEKP PNPMEGMTEE 480
QKEHEAMKLV TMFDKLSRNR VIQPMGMSPR GHLTSLQDAM CETMEQQLSS DPDSDPD 537 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005886; C:plasma membrane; ISS:UniProtKB. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IEA:Compara. GO:0071711; P:basement membrane organization; IEA:Compara. GO:0042074; P:cell migration involved in gastrulation; IEA:Compara. GO:0070586; P:cell-cell adhesion involved in gastrulation; IEA:Compara. GO:0001701; P:in utero embryonic development; IEA:Compara. GO:0001944; P:vasculature development; IEA:Compara. GO:0008542; P:visual learning; IEA:Compara. |
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