CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038734
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 D-2-hydroxyglutarate dehydrogenase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 D2hgdh 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
137KTVRGCSKVLLRPQTacetylation[1, 2]
137KTVRGCSKVLLRPQTsuccinylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 557 AA 
Protein Sequence
MRMLCACRVV FFRLSPLSRA GTMVLPLVSR WSARVLWASP GWRRTYTQRA CVGLKRLGCP 60
RGVYSPLAHR AYSVVAGGPE VTLTPERYPV QRLPFSTVSE EDLAAFECII PGRVITDPEQ 120
LQTCNVDWLK TVRGCSKVLL RPQTSEEVSQ ILRHCYKRNL AVNPQGGNTG MVGGSVPVFD 180
EVILSTALMN QVISFHDVSG ILVCQAGCVL EELSRYVQER DFIMPLDLGA KGSCHIGGNV 240
ATNAGGLRFL RYGSLRGTVL GLEVVLADGT ILNCLTSLRK DNTGYDLKQM FIGSEGTLGV 300
ITAVSIVCPP RPKAVNVAFL GCPGFAEVLQ TFRTCRGMLG EILSAFEFMD TECMQLVGQH 360
LQLTNPVQES PFYVLVETSG SSAGHDAEKL TNVLEQVLNS GLVTDGTMAT DQRKVQMLWA 420
LRERITEALS RDGYVFKYDL SLPVERLYDL VIDLRTRLGP RAKHVVGYGH LGDGNLHLNV 480
TAEAFSRELL GALEPYVYAW TAEQRGSVSA EHGLGFKKKD VLGYSKPPVA VTLMQQLKAM 540
LDPEGILNPY KTLPAQA 557 
Gene Ontology
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0008762; F:UDP-N-acetylmuramate dehydrogenase activity; IEA:InterPro. 
Interpro
 IPR016169; CO_DH_flavot_FAD-bd_sub2.
 IPR016166; FAD-bd_2.
 IPR016167; FAD-bd_2_sub1.
 IPR016164; FAD-linked_Oxase-like_C.
 IPR004113; FAD-linked_oxidase_C.
 IPR006094; Oxid_FAD_bind_N.
 IPR016171; Vanillyl_alc_oxidase_C-sub2. 
Pfam
 PF02913; FAD-oxidase_C
 PF01565; FAD_binding_4 
SMART
  
PROSITE
 PS51387; FAD_PCMH 
PRINTS