CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029755
UniProt Accession
Genbank Protein ID
 Z82244 
Genbank Nucleotide ID
  
Protein Name
 DNA replication licensing factor MCM5 
Protein Synonyms/Alias
  
Gene Name
 MCM5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
36SQLQRRFKEFLRQYRubiquitination[1]
173PSSIRSLKSDMMSHLubiquitination[1, 2, 3]
182DMMSHLVKIPGIIIAubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 231 AA 
Protein Sequence
MSGFDDPGIF YSDSFGGDAQ ADEGQARKSQ LQRRFKEFLR QYRVGTDRTG FTFKYSLAPS 60
LIEHLLPARY CSGCWAAALK LDLAPASRDE LKRHYNLGEY WIEVEMEDLA SFDEDLADYL 120
YKQPAEHLQL LEEAAKEVAD EVTRPRPSGE EVLQDIQVML KSDASPSSIR SLKSDMMSHL 180
VKIPGIIIAA SAVRAKATRI SIQCRSCRNT LTNIAMRPGL EGYALPRKCN T 231 
Gene Ontology
 GO:0042555; C:MCM complex; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003678; F:DNA helicase activity; IEA:InterPro.
 GO:0032508; P:DNA duplex unwinding; IEA:GOC.
 GO:0006270; P:DNA replication initiation; IEA:InterPro. 
Interpro
 IPR008048; MCM5.
 IPR012340; NA-bd_OB-fold. 
Pfam
  
SMART
  
PROSITE
  
PRINTS
 PR01661; MCMPROTEIN5.