CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012056
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Inactive tyrosine-protein kinase 7 
Protein Synonyms/Alias
 Colon carcinoma kinase 4; CCK-4; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7 
Gene Name
 PTK7 
Gene Synonyms/Alias
 CCK4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
181SNHTVSSKERNLTLRubiquitination[1]
764QPITTLGKSEFGEVFubiquitination[1]
795LVKSLQSKDEQQQLDubiquitination[1]
858KSKDEKLKSQPLSTKubiquitination[1]
1009RCWALSPKDRPSFSEubiquitination[1]
1029GDSTVDSKP******ubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. 
Sequence Annotation
 DOMAIN 31 120 Ig-like C2-type 1.
 DOMAIN 128 218 Ig-like C2-type 2.
 DOMAIN 225 317 Ig-like C2-type 3.
 DOMAIN 309 407 Ig-like C2-type 4.
 DOMAIN 412 497 Ig-like C2-type 5.
 DOMAIN 503 586 Ig-like C2-type 6.
 DOMAIN 578 680 Ig-like C2-type 7.
 DOMAIN 796 1066 Protein kinase; inactive.
 REGION 794 1070 Interaction with CTNNB1.
 CARBOHYD 116 116 N-linked (GlcNAc...).
 CARBOHYD 175 175 N-linked (GlcNAc...).
 CARBOHYD 184 184 N-linked (GlcNAc...) (Potential).
 CARBOHYD 214 214 N-linked (GlcNAc...) (Potential).
 CARBOHYD 268 268 N-linked (GlcNAc...).
 CARBOHYD 283 283 N-linked (GlcNAc...).
 CARBOHYD 405 405 N-linked (GlcNAc...) (Potential).
 CARBOHYD 463 463 N-linked (GlcNAc...) (Potential).
 CARBOHYD 567 567 N-linked (GlcNAc...) (Potential).
 CARBOHYD 646 646 N-linked (GlcNAc...).
 DISULFID 53 101 By similarity.
 DISULFID 150 200 By similarity.
 DISULFID 246 301 By similarity.
 DISULFID 343 391 By similarity.
 DISULFID 433 481 By similarity.
 DISULFID 524 570 By similarity.
 DISULFID 613 664 By similarity.  
Keyword
 Alternative splicing; Cell adhesion; Cell junction; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1070 AA 
Protein Sequence
MGAARGSPAR PRRLPLLSVL LLPLLGGTQT AIVFIKQPSS QDALQGRRAL LRCEVEAPGP 60
VHVYWLLDGA PVQDTERRFA QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN 120
IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNHTVSS 180
KERNLTLRPA GPEHSGLYSC CAHSAFGQAC SSQNFTLSIA DESFARVVLA PQDVVVARYE 240
EAMFHCQFSA QPPPSLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGIYR 300
CIGQGQRGPP IILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG 360
VRLPTHGRVY QKGHELVLAN IAESDAGVYT CHAANLAGQR RQDVNITVAT VPSWLKKPQD 420
SQLEEGKPGY LDCLTQATPK PTVVWYRNQM LISEDSRFEV FKNGTLRINS VEVYDGTWYR 480
CMSSTPAGSI EAQARVQVLD GSSLPEWVTD NAGTLHFARV TRDDAGNYTC IASNGPQGQI 540
RAHVQLTVAV FITFKVEPER TTVYQGHTAL LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR 600
MHIFQNGSLV IHDVAPEDSG RYTCIAGNSC NIKHTEAPLY VVDKPVPEES EGPGSPPPYK 660
MIQTIGLSVG AAVAYIIAVL GLMFYCKKRC KAKRLQKQPE GEEPEMECLN GGPLQNGQPS 720
AEIQEEVALT SLGSGPAATN KRHSTSDKMH FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE 780
GVAETLVLVK SLQSKDEQQQ LDFRRELEMF GKLNHANVVR LLGLCREAEP HYMVLEYVDL 840
GDLKQFLRIS KSKDEKLKSQ PLSTKQKVAL CTQVALGMEH LSNNRFVHKD LAARNCLVSA 900
QRQVKVSALG LSKDVYNSEY YHFRQAWVPL RWMSPEAILE GDFSTKSDVW AFGVLMWEVF 960
THGEMPHGGQ ADDEVLADLQ AGKARLPQPE GCPSKLYRLM QRCWALSPKD RPSFSEIASA 1020
LGDSTVDSKP 1030 
Gene Ontology
 GO:0005911; C:cell-cell junction; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; TAS:ProtInc.
 GO:0031532; P:actin cytoskeleton reorganization; IMP:UniProtKB.
 GO:0003401; P:axis elongation; IEA:Compara.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IMP:UniProtKB.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0016477; P:cell migration; IMP:UniProtKB.
 GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.
 GO:0090103; P:cochlea morphogenesis; IEA:Compara.
 GO:0060026; P:convergent extension; IEA:Compara.
 GO:0045198; P:establishment of epithelial cell apical/basal polarity; IEA:Compara.
 GO:0001736; P:establishment of planar polarity; IEA:Compara.
 GO:0060484; P:lung-associated mesenchyme development; IEA:Compara.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IEA:Compara.
 GO:0010976; P:positive regulation of neuron projection development; IMP:BHF-UCL.
 GO:0042060; P:wound healing; IEA:Compara. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom. 
Pfam
 PF07679; I-set
 PF07714; Pkinase_Tyr 
SMART
 SM00409; IG
 SM00408; IGc2
 SM00219; TyrKc 
PROSITE
 PS50835; IG_LIKE
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00239; RECEPTOR_TYR_KIN_II 
PRINTS
 PR00109; TYRKINASE.