CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007059
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Vacuolar protein sorting-associated protein 45 
Protein Synonyms/Alias
  
Gene Name
 VPS45 
Gene Synonyms/Alias
 STT10; VPL28; YGL095C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
20KIVTSQSKLSVANVNubiquitination[1]
311YVTTYKDKTQTNSQIubiquitination[1]
414NNQTSSDKIRQLVEIubiquitination[1]
496SLLTDLSKNALFRDRubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Essential for vacuolar protein sorting. Function in membrane traffic between the Golgi and the vacuole. 
Sequence Annotation
  
Keyword
 Complete proteome; Cytoplasm; Membrane; Protein transport; Reference proteome; Transport; Vacuole. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 577 AA 
Protein Sequence
MNLFDVADFY INKIVTSQSK LSVANVNEHQ RIKVLLLDKN TTPTISLCAT QSELLKHEIY 60
LVERIENEQR EVSRHLRCLV YVKPTEETLQ HLLRELRNPR YGEYQIFFSN IVSKSQLERL 120
AESDDLEAVT KVEEIFQDFF ILNQDLFSFD LQPREFLSNK LVWSEGGLTK CTNSLVSVLL 180
SLKIKPDIRY EGASKICERL AKEVSYEIGK NERTFFDFPV MDSTPVLLIL DRNTDPITPL 240
LQPWTYQSMI NEYIGIKRNI VDLSKVPRID KDLEKVTLSS KQDAFFRDTM YLNFGELGDK 300
VKQYVTTYKD KTQTNSQINS IEDIKNFIEK YPEFRKLSGN VAKHMAIVGE LDRQLKIKNI 360
WEISEIEQNL SAHDANEEDF SDLIKLLQNE AVDKYYKLKL ACIYSLNNQT SSDKIRQLVE 420
ILSQQLPPED VNFFHKFKSL FSRQDKMTQS NHDKDDILTE LARRFNSRMN SKSNTAENVY 480
MQHIPEISSL LTDLSKNALF RDRFKEIDTQ GHRVIGNQQS KDIPQDVILF VIGGVTYEEA 540
RLVHDFNGTM NNRMRVVLGG TSILSTKEYM DSIRSAK 577 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0019898; C:extrinsic to membrane; IDA:SGD.
 GO:0000139; C:Golgi membrane; IDA:SGD.
 GO:0031201; C:SNARE complex; IPI:SGD.
 GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
 GO:0051082; F:unfolded protein binding; IMP:SGD.
 GO:0032258; P:CVT pathway; IMP:SGD.
 GO:0006895; P:Golgi to endosome transport; IGI:SGD.
 GO:0006896; P:Golgi to vacuole transport; IMP:SGD.
 GO:0048210; P:Golgi vesicle fusion to target membrane; IMP:SGD.
 GO:0035543; P:positive regulation of SNARE complex assembly; IMP:SGD.
 GO:0007035; P:vacuolar acidification; IMP:SGD.
 GO:0000011; P:vacuole inheritance; IMP:SGD.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro. 
Interpro
 IPR027482; Sec-1-like_dom2.
 IPR001619; Sec1-like. 
Pfam
 PF00995; Sec1 
SMART
  
PROSITE
  
PRINTS