UniProt Accession

 TAD2A_HUMAN; O75478; A8MVD0; B3KMU9; Q9BVJ0; Q9UCW2; Q9UP49 

Genbank Protein ID

 AF064094; AK022767; AC004099; AC068400; AC068447; BC001172; BC011753; AF069732 

Genbank Nucleotide ID

 AAC26659.1; BAG51111.1; AAH01172.1; AAH11753.1; AAC39902.1 

Protein Name

 Transcriptional adapter 2-alpha 

Protein Synonyms/Alias

 Transcriptional adapter 2-like; ADA2-like protein 

Gene Name

 TADA2A 

Gene Synonyms/Alias

 TADA2L; KL04P 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
132	ASTLLNLKQAEEAKT	ubiquitination	[1]
138	LKQAEEAKTADTAIP	ubiquitination	[1]
235	HGLINLRKFQLMERR	ubiquitination	[1]
375	TGLPGTEKLNEKEKE	ubiquitination	[1]
381	EKLNEKEKELCQMVR	acetylation	[2]
381	EKLNEKEKELCQMVR	ubiquitination	[1]
398	PGAYLEYKSALLNEC	ubiquitination	[1]
407	ALLNECNKQGGLRLA	ubiquitination	[1]
421	AQARALIKIDVNKTR	ubiquitination	[1]
429	IDVNKTRKIYDFLIR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. 

Sequence Annotation

 DOMAIN 70 122 SANT.
 DOMAIN 356 443 SWIRM.
 DNA_BIND 426 435 By similarity.  

Keyword

 3D-structure; Alternative splicing; Chromosome; Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 443 AA 

Protein Sequence

Gene Ontology

 GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IEA:Compara.
 GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
 GO:0072686; C:mitotic spindle; IEA:Compara.
 GO:0000125; C:PCAF complex; IDA:UniProtKB.
 GO:0003682; F:chromatin binding; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0003712; F:transcription cofactor activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0043966; P:histone H3 acetylation; IDA:UniProtKB.
 GO:0007067; P:mitosis; IEA:Compara.
 GO:0031063; P:regulation of histone deacetylation; IEA:Compara.
 GO:0001932; P:regulation of protein phosphorylation; IEA:Compara.
 GO:0031647; P:regulation of protein stability; IEA:Compara.
 GO:0090043; P:regulation of tubulin deacetylation; IEA:Compara.
 GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR009057; Homeodomain-like.
 IPR001005; SANT/Myb.
 IPR017884; SANT_dom.
 IPR007526; SWIRM.
 IPR016827; Transcriptional_adaptor_2.
 IPR000433; Znf_ZZ. 

Pfam

 PF00249; Myb_DNA-binding
 PF04433; SWIRM 

SMART

 SM00717; SANT
 SM00291; ZnF_ZZ 

PROSITE

 PS51293; SANT
 PS50934; SWIRM 

PRINTS