| Tag | Content |
|---|
| CPLM ID | CPLM-021825 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | RNA-binding protein Nova-1 |
Protein Synonyms/Alias | Neuro-oncological ventral antigen 1; Ventral neuron-specific protein 1 |
Gene Name | Nova1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 439 | LVGAILGKGGKTLVE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion. It binds specifically to the sequence UCAUY. Most likely acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma-2 subunit via a distal downstream UCAU-rich intronic splicing enhancer. |
Sequence Annotation | DOMAIN 49 116 KH 1.
DOMAIN 171 237 KH 2.
DOMAIN 421 488 KH 3.
MOTIF 27 43 Bipartite nuclear localization signal
MOD_RES 154 154 Phosphoserine. |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 507 AA |
Protein Sequence | MMAAAPIQQN GTHTGVPIDL DPPDSRKRPL EAPPEAGSTK RTNTGEDGQY FLKVLIPSYA 60
AGSIIGKGGQ TIVQLQKETG ATIKLSKSKD FYPGTTERVC LIQGTIEALN AVHGFIAEKI 120
REMPQNVAKT EPVSILQPQT TVNPDRIKQT LPSSPTTTKS SPSDPMTTSR ANQVKIIVPN 180
STAGLIIGKG GATVKAIMEQ SGAWVQLSQK PDGINLQERV VTVSGEPEQN RKAVELIIQK 240
IQEDPQSGSC LNISYANVTG PVANSNPTGS PYANTAEVLP TAAAAAGLLG HANLAGVAAF 300
PAVLSGFTGN DLVAITSALN TLASYGYNLN TLGLGLSQAA ATGALAAAAA SANPAAAAAN 360
LLATYASEAS ASGSTAGGTA GTFALGSLAA ATAATNGYFG AASPLAASAI LGTEKSTDGS 420
KDVVEIAVPE NLVGAILGKG GKTLVEYQEL TGARIQISKK GEFVPGTRNR KVTITGTPAA 480
TQAAQYLITQ RITYEQGVRA ANPQKVG 507 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |