UniProt Accession

 CX6B1_HUMAN; P14854; B2R5C9; Q6IBL4 

Genbank Protein ID

 X13923; X54473; AK312140; BT006945; CR456789; CR542137; AC002115; BC001015; BC002478; X58139 

Genbank Nucleotide ID

 CAA32114.1; CAA38352.1; BAG35076.1; AAP35591.1; CAG33070.1; CAG46934.1; AAB57628.1; AAH01015.1; AAH02478.1; CAA41147.1 

Protein Name

 Cytochrome c oxidase subunit 6B1 

Protein Synonyms/Alias

 Cytochrome c oxidase subunit VIb isoform 1; COX VIb-1 

Gene Name

 COX6B1 

Gene Synonyms/Alias

 COX6B 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MAEDMETKIKNYKTA	ubiquitination	[1, 2, 3]
10	EDMETKIKNYKTAPF	ubiquitination	[2]
13	ETKIKNYKTAPFDSR	ubiquitination	[2, 4, 5, 6]
42	LDFHRCQKAMTAKGG	ubiquitination	[7]
47	CQKAMTAKGGDISVC	ubiquitination	[1, 2, 3, 4, 6, 7, 8]
85	AEGTFPGKI******	ubiquitination	[1, 2, 3, 8]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [7] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [8] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Connects the two COX monomers into the physiological dimeric form (By similarity). 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 DISULFID 30 65 By similarity.
 DISULFID 40 54 By similarity.  

Keyword

 Acetylation; Complete proteome; Disease mutation; Disulfide bond; Mitochondrion; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 86 AA 

Protein Sequence

Gene Ontology

 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
 GO:0004129; F:cytochrome-c oxidase activity; NAS:UniProtKB.
 GO:0022904; P:respiratory electron transport chain; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR003213; Cyt_c_oxidase_su6B. 

Pfam

 PF02297; COX6B 

SMART

  

PROSITE

  

PRINTS