CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039024
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein argonaute-2 
Protein Synonyms/Alias
  
Gene Name
 Ago2 
Gene Synonyms/Alias
 Eif2c2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
254SQRVKFTKEIKGLKVacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 853 AA 
Protein Sequence
VLASPAPTTS PIPGYAFKPP PRPDFGTTGR TIKLQANFFE MDIPKIDIYH YELDIKPEKC 60
PRRVNREIVE HMVQHFKTQI FGDRKPVFDG RKNLYTAMPL PIGRDKVELE VTLPGEGKDR 120
IFKVSIKWVS CVSLQALHDA LSGRLPSVPF ETIQALDVVM RHLPSMRYTP VGRSFFTASE 180
GCSNPLGGGR EVWFGFHQSV RPSLWKMMLN IDVSATAFYK AQPVIEFVCE VLDFKSIEEQ 240
QKPLTDSQRV KFTKEIKGLK VEITHCGQMK RKYRVCNVTR RPASHQTFPL QQESGQTVEC 300
TVAQYFKDRH KLVLRYPHLP CLQVGQEQKH TYLPLEVCNI VAGQRCIKKL TDNQTSTMIR 360
ATARSAPDRQ EEISKLMRSA SFNTDPYVRE FGIMVKDEMT DVTGRVLQPP SILYGGRNKA 420
IATPVQGVWD MRNKQFHTGI EIKVWAIACF APQRQCTEVH LKSFTEQLRK ISRDAGMPIQ 480
GQPCFCKYAQ GADSVEPMFR HLKNTYAGLQ LVVVILPGKT PVYAEVKRVG DTVLGMATQC 540
VQMKNVQRTT PQTLSNLCLK INVKLGGVNN ILLPQGRPPV FQQPVIFLGA DVTHPPAGDG 600
KKPSIAAVVG SMDAHPNRYC ATVRVQQHRQ EIIQDLAAMV RELLIQFYKS TRFKPTRIIF 660
YRDGVSEGQF QQVLHHELLA IREACIKLEK DYQPGITFIV VQKRHHTRLF CTDKNERVGK 720
SGNIPAGTTV DTKITHPTEF DFYLCSHAGI QGTSRPSHYH VLWDDNRFSS DELQILTYQL 780
CHTYVRCTRS VSIPAPAYYA HLVAFRARYH LVDKEHDSAE GSHTSGQSNG RDHQALAKAV 840
QVHQDTLRTM YFA 853 
Gene Ontology
 GO:0000932; C:cytoplasmic mRNA processing body; IEA:Compara.
 GO:0035068; C:micro-ribonucleoprotein complex; IEA:Compara.
 GO:0005845; C:mRNA cap binding complex; IEA:Compara.
 GO:0005844; C:polysome; IEA:Compara.
 GO:0016442; C:RNA-induced silencing complex; IEA:Compara.
 GO:0070551; F:endoribonuclease activity, cleaving siRNA-paired mRNA; IEA:Compara.
 GO:0003729; F:mRNA binding; IEA:Compara.
 GO:0000340; F:RNA 7-methylguanosine cap binding; IEA:Compara.
 GO:0035197; F:siRNA binding; IEA:Compara.
 GO:0035279; P:mRNA cleavage involved in gene silencing by miRNA; IEA:Compara.
 GO:0035278; P:negative regulation of translation involved in gene silencing by miRNA; IEA:Compara.
 GO:0045947; P:negative regulation of translational initiation; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0031054; P:pre-miRNA processing; IEA:Compara. 
Interpro
 IPR014811; DUF1785.
 IPR003100; PAZ.
 IPR003165; Piwi.
 IPR012337; RNaseH-like_dom. 
Pfam
 PF08699; DUF1785
 PF02170; PAZ
 PF02171; Piwi 
SMART
 SM00949; PAZ
 SM00950; Piwi 
PROSITE
 PS50821; PAZ
 PS50822; PIWI 
PRINTS