UniProt Accession

 LTMD1_MOUSE; Q924L1; Q3TF05; Q3U3M7; Q8BLG9; Q8K1F7; Q8VDS9 

Genbank Protein ID

 AF287293; AF401483; AK045256; AK080221; AK154676; AK169341; BC021361 

Genbank Nucleotide ID

 AAK83032.1; AAM90666.1; BAC32283.1; BAC37851.1; BAE32758.1; BAE41093.1; AAH21361.1 

Protein Name

 LETM1 domain-containing protein 1 

Protein Synonyms/Alias

 Cervical cancer receptor; MCC-32 

Gene Name

 Letmd1 

Gene Synonyms/Alias

 Mccr 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
209	STFVSHEKLRRQLTD	acetylation	[1, 2]
292	QLDRALAKLGIGQLT	acetylation	[1, 3]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

 Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. 

Sequence Annotation

 DOMAIN 75 346 LETM1.
 REGION 1 110 Required and sufficient for mitochondrial  

Keyword

 Alternative splicing; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Proto-oncogene; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 360 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IDA:MGI. 

Interpro

 IPR011685; LETM1. 

Pfam

 PF07766; LETM1 

SMART

  

PROSITE

  

PRINTS