UniProt Accession

 H0YLF3_HUMAN; H0YLF3 

Genbank Protein ID

 AC025270; AC122108 

Genbank Nucleotide ID

  

Protein Name

 Beta-2-microglobulin form pI 5.3 

Protein Synonyms/Alias

  

Gene Name

 B2M 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	LSQPKIVKWDRDM**	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Immunity; Immunoglobulin domain; MHC I; Reference proteome; Secreted. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 71 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0002481; P:antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; IEA:Compara.
 GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Compara.
 GO:0042026; P:protein refolding; IEA:Compara.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0002237; P:response to molecule of bacterial origin; IEA:Compara.
 GO:0033077; P:T cell differentiation in thymus; IEA:Compara. 

Interpro

 IPR015707; B2Microglobulin.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set. 

Pfam

 PF07654; C1-set 

SMART

 SM00407; IGc1 

PROSITE

 PS00290; IG_MHC 

PRINTS