CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-044426
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Piezo-type mechanosensitive ion channel component 1 
Protein Synonyms/Alias
  
Gene Name
 PIEZO1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
56FVKEKLLKWAESPAAubiquitination[1, 2, 3]
726KKEGPARKGAAAIEAubiquitination[2, 3]
745EEEGEEEKEAPTGREubiquitination[1, 2, 3]
795FHDILHTKYRAATDVubiquitination[1, 2, 4, 5]
1321PCVDRILKLCQDIFLubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1363 AA 
Protein Sequence
XMDLRPELPT TLGPVSLRQL GLEHTRYPCL DLGAMLLYTL TFWLLLRQFV KEKLLKWAES 60
PAALTEVTVA DTEPTRTQTL LQSLGELVKG VYAKYWIYVC AGMFIVVSFA GRLVVYKIVY 120
MFLFLLCLTL FQVYYSLWRK LLKAFWWLVV AYTMLVLIAV YTFQFQDFPA YWRNLTGFTD 180
EQLGDLGLEQ FSVSELFSSI LVPGFFLLAC ILQLHYFHRP FMQLTDMEHV SLPGTRLPRW 240
AHRQDAVSGT PLLREEQQEH QQQQQEEEEE EEDSRDEGLG VATPHQATQV PEGAAKWGLV 300
AERLLELAAG FSDVLSRVQV FLRRLLELHV FKLVALYTVW VALKEVSVMN LLLVVLWAFA 360
LPYPRFRPMA SCLSTVWTCV IIVCKMLYQL KVVNPQEYSS NCTEPFPNST NLLPTEISQS 420
LLYRGPVDPA NWFGVRKGFP NLGYIQNHLQ VLLLLVFEAI VYRRQEHYRR QHQLAPLPAQ 480
AVFASGTRQQ LDQDLLGCLK YFINFFFYKF GLEICFLMAV NVIGQRMNFL VTLHGCWLVA 540
ILTRRHRQAI ARLWPNYCLF LALFLLYHKR FWMTAIVFTE IAVVVKYLFQ FGFFPWNSHV 600
VLRRYENKPY FPPRILGLEK TDGYIKYDLV QLMALFFHRS QLLCYGLWDH EEDSPSKEHD 660
KSGEEEQGAE EGPGVPAATT EDHIQVEARV GPTDGTPEPQ VELRPRDTRR ISLRFRRRKK 720
EGPARKGAAA IEAEDREEEE GEEEKEAPTG REKRPSRSGG RVRAAGRRLQ GFCLSLAQGT 780
YRPLRRFFHD ILHTKYRAAT DVYALMFLAD VVDFIIIIFG FWAFGKHSAA TDITSSLSDD 840
QVPEAFLVML LIQFSTMVVD RALYLRKTVL GKLAFQVALV LAIHLWMFFI LPAVTERMFN 900
QNVVAQLWYF VKCIYFALSA YQIRCGYPTR ILGNFLTKKY NHLNLFLFQG FRLVPFLVEL 960
RAVMDWVWTD TTLSLSSWMC VEDIYANIFI IKCSRETEKK YPQPKGQKKK KIVKYGMGGL 1020
IILFLIAIIW FPLLFMSLVR SVVGVVNQPI DVTVTLKLGG YEPLFTMSAQ QPSIIPFTAQ 1080
AYEELSRQFD PQPLAMQFIS QYSPEDIVTA QIEGSSGALW RISPPSRAQM KRELYNGTAD 1140
ITLRFTWNFQ RDLAKGGTVE YANEKHMLAL APNSTARRQL ASLLEGTSDQ SVVIPNLFPK 1200
YIRAPNGPEA NPVKQLQPNE EADYLGVRIQ LRREQGAGAT GFLEWWVIEL QECRTDCNLL 1260
PMVIFSDKVS PPSLGFLAGY GIMGLYVSIV LVIGKFVRGF FSEISHSIMF EELPCVDRIL 1320
KLCQDIFLVR ETRELELEEE LYAKLIFLYR SPETMIKWTR EKE 1363 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0008381; F:mechanically-gated ion channel activity; IEA:InterPro. 
Interpro
 IPR027272; Piezo. 
Pfam
 PF12166; DUF3595 
SMART
  
PROSITE
  
PRINTS