CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020308
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Stimulated by retinoic acid gene 6 protein homolog 
Protein Synonyms/Alias
  
Gene Name
 STRA6 
Gene Synonyms/Alias
 PP14296; UNQ3126/PRO10282/PRO19578 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
231RRTGAGSKGLQSSYSubiquitination[1]
259GSSYHTSKHGFLSWAubiquitination[1]
612GMQLLQTKDSMAKGAubiquitination[1]
617QTKDSMAKGARPGASubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex (By similarity). 
Sequence Annotation
 CARBOHYD 8 8 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Cell membrane; Complete proteome; Disease mutation; Glycoprotein; Membrane; Microphthalmia; Polymorphism; Receptor; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 667 AA 
Protein Sequence
MSSQPAGNQT SPGATEDYSY GSWYIDEPQG GEELQPEGEV PSCHTSIPPG LYHACLASLS 60
ILVLLLLAML VRRRQLWPDC VRGRPGLPRP RAVPAAVFMV LLSSLCLLLP DEDALPFLTL 120
ASAPSQDGKT EAPRGAWKIL GLFYYAALYY PLAACATAGH TAAHLLGSTL SWAHLGVQVW 180
QRAECPQVPK IYKYYSLLAS LPLLLGLGFL SLWYPVQLVR SFSRRTGAGS KGLQSSYSEE 240
YLRNLLCRKK LGSSYHTSKH GFLSWARVCL RHCIYTPQPG FHLPLKLVLS ATLTGTAIYQ 300
VALLLLVGVV PTIQKVRAGV TTDVSYLLAG FGIVLSEDKQ EVVELVKHHL WALEVCYISA 360
LVLSCLLTFL VLMRSLVTHR TNLRALHRGA ALDLSPLHRS PHPSRQAIFC WMSFSAYQTA 420
FICLGLLVQQ IIFFLGTTAL AFLVLMPVLH GRNLLLFRSL ESSWPFWLTL ALAVILQNMA 480
AHWVFLETHD GHPQLTNRRV LYAATFLLFP LNVLVGAMVA TWRVLLSALY NAIHLGQMDL 540
SLLPPRAATL DPGYYTYRNF LKIEVSQSHP AMTAFCSLLL QAQSLLPRTM AAPQDSLRPG 600
EEDEGMQLLQ TKDSMAKGAR PGASRGRARW GLAYTLLHNP TLQVFRKTAL LGANGAQP 658 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0043234; C:protein complex; IDA:LIFEdb.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0051183; F:vitamin transporter activity; IEA:InterPro.
 GO:0030325; P:adrenal gland development; IMP:DFLAT.
 GO:0061143; P:alveolar primary septum development; IMP:DFLAT.
 GO:0048589; P:developmental growth; IMP:DFLAT.
 GO:0060539; P:diaphragm development; IMP:DFLAT.
 GO:0048546; P:digestive tract morphogenesis; IMP:DFLAT.
 GO:0097070; P:ductus arteriosus closure; IMP:DFLAT.
 GO:0043583; P:ear development; IMP:DFLAT.
 GO:0060900; P:embryonic camera-type eye formation; IMP:DFLAT.
 GO:0048566; P:embryonic digestive tract development; IMP:DFLAT.
 GO:0061029; P:eyelid development in camera-type eye; IMP:DFLAT.
 GO:0060325; P:face morphogenesis; IMP:DFLAT.
 GO:0007631; P:feeding behavior; IMP:DFLAT.
 GO:0030540; P:female genitalia development; IMP:DFLAT.
 GO:0001822; P:kidney development; IMP:DFLAT.
 GO:0060426; P:lung vasculature development; IMP:DFLAT.
 GO:0050905; P:neuromuscular process; IMP:DFLAT.
 GO:0043585; P:nose morphogenesis; IMP:DFLAT.
 GO:0061205; P:paramesonephric duct development; IMP:DFLAT.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0048520; P:positive regulation of behavior; IMP:DFLAT.
 GO:0061156; P:pulmonary artery morphogenesis; IMP:DFLAT.
 GO:0003184; P:pulmonary valve morphogenesis; IMP:DFLAT.
 GO:0042573; P:retinoic acid metabolic process; IEA:Compara.
 GO:0001523; P:retinoid metabolic process; TAS:Reactome.
 GO:0048745; P:smooth muscle tissue development; IMP:DFLAT.
 GO:0061038; P:uterus morphogenesis; IMP:DFLAT.
 GO:0003281; P:ventricular septum development; IMP:DFLAT.
 GO:0071939; P:vitamin A import; IEA:Compara.
 GO:0042297; P:vocal learning; IMP:DFLAT. 
Interpro
 IPR026612; STRA6. 
Pfam
  
SMART
  
PROSITE
  
PRINTS