CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034430
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Acyl-CoA-binding protein 
Protein Synonyms/Alias
  
Gene Name
 Dbi 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
27RPGLLDLKGKAKWDSacetylation[1, 2, 3, 4, 5, 6, 7]
27RPGLLDLKGKAKWDSsuccinylation[6]
27RPGLLDLKGKAKWDSubiquitination[8]
31LDLKGKAKWDSWNKLacetylation[1, 2, 3, 4, 5, 6, 7]
31LDLKGKAKWDSWNKLphosphoglycerylation[9]
31LDLKGKAKWDSWNKLsuccinylation[6]
31LDLKGKAKWDSWNKLubiquitination[8]
37AKWDSWNKLKGTSKEacetylation[3, 6]
37AKWDSWNKLKGTSKEsuccinylation[6]
37AKWDSWNKLKGTSKEubiquitination[8]
48TSKESAMKTYVEKVDacetylation[6]
48TSKESAMKTYVEKVDsuccinylation[6]
48TSKESAMKTYVEKVDubiquitination[8]
53AMKTYVEKVDELKKKacetylation[1, 2, 3, 4, 6, 7, 10]
53AMKTYVEKVDELKKKsuccinylation[6]
53AMKTYVEKVDELKKKubiquitination[8]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [7] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [8] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [9] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237]
 [10] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 63 AA 
Protein Sequence
MLFIYSHFKQ ATVGDVNTDR PGLLDLKGKA KWDSWNKLKG TSKESAMKTY VEKVDELKKK 60
YGI 63 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0000062; F:fatty-acyl-CoA binding; IEA:InterPro.
 GO:0001942; P:hair follicle development; IMP:MGI.
 GO:0043588; P:skin development; IMP:MGI.
 GO:0006641; P:triglyceride metabolic process; IMP:MGI. 
Interpro
 IPR000582; Acyl-CoA-binding_protein.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx. 
Pfam
 PF00887; ACBP 
SMART
  
PROSITE
 PS51228; ACB_2 
PRINTS
 PR00689; ACOABINDINGP.