CPLM-009606

Genbank Nucleotide ID

60S ribosomal protein L30

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
8	MVAAKKTKKSLESIN	ubiquitination	[1]
9	VAAKKTKKSLESINS	ubiquitination	[1, 2, 3, 4, 5]
23	SRLQLVMKSGKYVLG	ubiquitination	[1, 3, 4, 5]
26	QLVMKSGKYVLGYKQ	acetylation	[6]
26	QLVMKSGKYVLGYKQ	ubiquitination	[1, 2, 3, 4, 5, 7]
32	GKYVLGYKQTLKMIR	ubiquitination	[1, 2, 3, 4, 5]
36	LGYKQTLKMIRQGKA	ubiquitination	[1, 3]
44	MIRQGKAKLVILANN	ubiquitination	[1, 2, 4]
57	NNCPALRKSEIEYYA	ubiquitination	[1, 2]
68	EYYAMLAKTGVHHYS	ubiquitination	[1, 2]
87	ELGTACGKYYRVCTL	ubiquitination	[8]
115	MPEQTGEK*******	ubiquitination	[3, 9]

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[4] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[6] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
[7] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
[8] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
[9] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]

Functional Description

MOD_RES 10 10 Phosphoserine.
MOD_RES 26 26 N6-acetyllysine.

3D-structure; Acetylation; Complete proteome; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0022625; C:cytosolic large ribosomal subunit; IDA:UniProtKB.
GO:0003723; F:RNA binding; TAS:UniProtKB.
GO:0003735; F:structural constituent of ribosome; NAS:UniProtKB.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
GO:0006414; P:translational elongation; TAS:Reactome.
GO:0006413; P:translational initiation; TAS:Reactome.
GO:0006415; P:translational termination; TAS:Reactome.
GO:0019083; P:viral transcription; TAS:Reactome.

IPR000231; Ribosomal_L30e.
IPR022991; Ribosomal_L30e_CS.
IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.

PF01248; Ribosomal_L7Ae

PS00709; RIBOSOMAL_L30E_1
PS00993; RIBOSOMAL_L30E_2