UniProt Accession

 OXYR_HUMAN; P30559; Q15071 

Genbank Protein ID

 X64878; AY389507; X80282 

Genbank Nucleotide ID

 CAA46097.1; AAQ91333.1; CAA56562.1 

Protein Name

 Oxytocin receptor 

Protein Synonyms/Alias

 OT-R 

Gene Name

 OXTR 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
234	IWQNLRLKTAAAAAA	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system. 

Sequence Annotation

 CARBOHYD 8 8 N-linked (GlcNAc...) (Potential).
 CARBOHYD 15 15 N-linked (GlcNAc...) (Potential).
 CARBOHYD 26 26 N-linked (GlcNAc...) (Potential).
 DISULFID 112 187 By similarity.  

Keyword

 Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 389 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0005913; C:cell-cell adherens junction; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005902; C:microvillus; IEA:Compara.
 GO:0004990; F:oxytocin receptor activity; TAS:ProtInc.
 GO:0017046; F:peptide hormone binding; IEA:Compara.
 GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
 GO:0048565; P:digestive tract development; IEA:Compara.
 GO:0042755; P:eating behavior; IEA:Compara.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IEA:Compara.
 GO:0070371; P:ERK1 and ERK2 cascade; IEA:Compara.
 GO:0060206; P:estrous cycle phase; IEA:Compara.
 GO:0007565; P:female pregnancy; TAS:ProtInc.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0007595; P:lactation; TAS:ProtInc.
 GO:0042711; P:maternal behavior; IEA:Compara.
 GO:0060137; P:maternal process involved in parturition; IEA:Compara.
 GO:0007613; P:memory; IEA:Compara.
 GO:0006936; P:muscle contraction; TAS:ProtInc.
 GO:0060455; P:negative regulation of gastric acid secretion; IEA:Compara.
 GO:0045777; P:positive regulation of blood pressure; IEA:Compara.
 GO:0010701; P:positive regulation of norepinephrine secretion; IEA:Compara.
 GO:0060406; P:positive regulation of penile erection; IEA:Compara.
 GO:0051965; P:positive regulation of synapse assembly; IEA:Compara.
 GO:0032230; P:positive regulation of synaptic transmission, GABAergic; IEA:Compara.
 GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IEA:Compara.
 GO:0070474; P:positive regulation of uterine smooth muscle contraction; IEA:Compara.
 GO:0001975; P:response to amphetamine; IEA:Compara.
 GO:0034059; P:response to anoxia; IEA:Compara.
 GO:0042220; P:response to cocaine; IEA:Compara.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0043434; P:response to peptide hormone stimulus; IEA:Compara.
 GO:0032570; P:response to progesterone stimulus; IEA:Compara.
 GO:0030431; P:sleep; IEA:Compara.
 GO:0035176; P:social behavior; IEA:Compara.
 GO:0042713; P:sperm ejaculation; IEA:Compara.
 GO:0001967; P:suckling behavior; IEA:Compara.
 GO:0021537; P:telencephalon development; IEA:Compara. 

Interpro

 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR002062; Oxytocn_rcpt.
 IPR001817; Vasoprsn_rcpt. 

Pfam

 PF00001; 7tm_1 

SMART

  

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 

PRINTS

 PR00237; GPCRRHODOPSN.
 PR00665; OXYTOCINR.
 PR00896; VASOPRESSINR.