CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016876
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sphingosine-1-phosphate lyase 1 
Protein Synonyms/Alias
 S1PL; SP-lyase 1; SPL; SPL 1; Sphingosine-1-phosphate aldolase 
Gene Name
 Sgpl1 
Gene Synonyms/Alias
 Spl 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
114KLDKDYVKTLPAQGLacetylation[1]
228YRDLALEKGIKTPEIacetylation[1]
342KPFDFRVKGVTSISAacetylation[1]
353SISADTHKYGYAPKGacetylation[1]
370VVMYSNEKYRKYQFFacetylation[1]
425EATKQIIKTARFLKSacetylation[1]
431IKTARFLKSELENIKacetylation[1]
513ESVTQIMKNPKAKTTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). 
Sequence Annotation
 MOD_RES 353 353 N6-(pyridoxal phosphate)lysine; alternate
 MOD_RES 353 353 N6-acetyllysine; alternate (By
 MOD_RES 356 356 Nitrated tyrosine (By similarity).
 MOD_RES 366 366 Nitrated tyrosine (By similarity).
 MOD_RES 564 564 Phosphoserine (By similarity).  
Keyword
 Acetylation; Apoptosis; Complete proteome; Endoplasmic reticulum; Lipid metabolism; Lyase; Membrane; Nitration; Phosphoprotein; Pyridoxal phosphate; Reference proteome; Signal-anchor; Sphingolipid metabolism; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 568 AA 
Protein Sequence
MPSTDLLKLK DFEPYLEILE AYSTKAKNYV NGYCTKYEPW QLIAGSVLCT LLVVWVYELI 60
FQPESLWSRF KNKLFRLIRK MPFIGRKIQQ QLTKAKKDLV KNMPFLKLDK DYVKTLPAQG 120
LSTAEVLERL KEYSSMDVFW QEGKASGAVY SGEPKLTELL VQAYGEFTWS NPLHPDIFPG 180
LRKLEAEIVR MTCSLFNGGP DSCGCVTSGG TESILMACKA YRDLALEKGI KTPEIVAPES 240
AHAAFDKAAH YFGMKIVRVA QKKNMEVDVR AMKRAISRNT AMLVCSAPQF PHGVIDPIPE 300
VAKLAVKYKI PFHVDACLGG FLIVFMEKAG YPLEKPFDFR VKGVTSISAD THKYGYAPKG 360
SSVVMYSNEK YRKYQFFVDA DWQGGIYASP SIAGSRPGGI IAACWAALMH FGENGYVEAT 420
KQIIKTARFL KSELENIKNI FILGDPQLSV IALGSNDFDI YRLSNMMSAK GWNFNYLQFP 480
RSIHFCITLV HTRKRVAIQF LKDIRESVTQ IMKNPKAKTT GMGAIYGMAQ ATIDRKMVAE 540
ISSVFLDSLY STDPVTQGNQ MNGSPKPR 568 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016831; F:carboxy-lyase activity; IEA:InterPro.
 GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
 GO:0008117; F:sphinganine-1-phosphate aldolase activity; IEA:EC.
 GO:0008209; P:androgen metabolic process; IEA:Compara.
 GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
 GO:0006672; P:ceramide metabolic process; ISS:UniProtKB.
 GO:0008210; P:estrogen metabolic process; IEA:Compara.
 GO:0097194; P:execution phase of apoptosis; ISS:UniProtKB.
 GO:0060325; P:face morphogenesis; IEA:Compara.
 GO:0010761; P:fibroblast migration; IEA:Compara.
 GO:0030097; P:hemopoiesis; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0033327; P:Leydig cell differentiation; IEA:Compara.
 GO:0001553; P:luteinization; IEA:Compara.
 GO:0060021; P:palate development; IEA:Compara.
 GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0040014; P:regulation of multicellular organism growth; IEA:Compara.
 GO:0048705; P:skeletal system morphogenesis; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara.
 GO:0001570; P:vasculogenesis; IEA:Compara. 
Interpro
 IPR002129; PyrdxlP-dep_de-COase.
 IPR015424; PyrdxlP-dep_Trfase.
 IPR015421; PyrdxlP-dep_Trfase_major_sub1. 
Pfam
 PF00282; Pyridoxal_deC 
SMART
  
PROSITE
 PS00392; DDC_GAD_HDC_YDC 
PRINTS