CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000555
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Fractalkine 
Protein Synonyms/Alias
 C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1; Processed fractalkine 
Gene Name
 Cx3cl1 
Gene Synonyms/Alias
 Cx3c; Fkn; Scyd1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
369SLQGCPRKMAGEMVEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (By similarity). Binds to CX3CR1. 
Sequence Annotation
 REGION 25 100 Chemokine.
 REGION 101 336 Mucin-like stalk.
 DISULFID 32 58 By similarity.
 DISULFID 36 74 By similarity.  
Keyword
 Cell adhesion; Cell membrane; Chemotaxis; Complete proteome; Cytokine; Disulfide bond; Membrane; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 395 AA 
Protein Sequence
MAPSPLAWLL RLAAFFHLCT LLPGQHLGMT KCEIMCDKMT SRIPVALLIR YQLNQESCGK 60
RAIVLETTQH RRFCADPKEK WVQDAMKHLD HQAAALTKNG GKFEKRVDNV TPGITLATRG 120
LSPSALTKPE SATLEDLALE LTTISQEARG TMGTSQEPPA AVTGSSLSTS EAQDAGLTAK 180
PQSIGSFEAA DISTTVWPSP AVYQSGSSSW AEEKATESPS TTAPSPQVST TSPSTPEENV 240
GSEGQPPWVQ GQDLSPEKSL GSEEINPVHT DNFQERGPGN TVHPSVAPIS SEETPSPELV 300
ASGSQAPKIE EPIHATADPQ KLSVLITPVP DTQAATRRQA VGLLAFLGLL FCLGVAMFAY 360
QSLQGCPRKM AGEMVEGLRY VPRSCGSNSY VLVPV 395 
Gene Ontology
 GO:0009986; C:cell surface; IDA:MGI.
 GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0008009; F:chemokine activity; IDA:MGI.
 GO:0060055; P:angiogenesis involved in wound healing; IMP:MGI.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0019221; P:cytokine-mediated signaling pathway; IMP:MGI.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0048247; P:lymphocyte chemotaxis; IDA:MGI.
 GO:0048246; P:macrophage chemotaxis; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0030593; P:neutrophil chemotaxis; IDA:MGI.
 GO:0045766; P:positive regulation of angiogenesis; IMP:MGI.
 GO:0051041; P:positive regulation of calcium-independent cell-cell adhesion; IEA:Compara.
 GO:0050729; P:positive regulation of inflammatory response; IEA:Compara.
 GO:0032914; P:positive regulation of transforming growth factor beta1 production; IMP:MGI.
 GO:0042060; P:wound healing; IMP:MGI. 
Interpro
 IPR008097; Chemokine_CX3CL1.
 IPR001811; Chemokine_IL8-like_dom. 
Pfam
 PF00048; IL8 
SMART
 SM00199; SCY 
PROSITE
  
PRINTS
 PR01721; FRACTALKINE.