| Tag | Content |
|---|
| CPLM ID | CPLM-003210 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | HTH-type transcriptional regulator UlaR |
Protein Synonyms/Alias | |
Gene Name | ulaR |
Gene Synonyms/Alias | yjfQ; b4191; JW4149 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 48 | NKLDESGKLKKVRNG | acetylation | [1] | | 80 | QAQNHDEKVRIAKAA | acetylation | [1] | | 173 | HWMFTSGKGLTAEGL | acetylation | [1] | | 182 | LTAEGLYKTDMLTAM | acetylation | [1] | | 193 | LTAMAEQKMLSVVGK | acetylation | [1] | | 209 | VVLVDSSKIGERAGM | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Represses ulaG and the ulaABCDEF operon. Two ulaR binding sites have been identified in each promoter. Full activity requires simultaneous interaction of UlaR with both divergent promoters and seems to be dependent on repressor-mediated DNA loop formation, which is helped by the action of integration host factor. |
Sequence Annotation | DOMAIN 3 58 HTH deoR-type.
DNA_BIND 20 39 H-T-H motif (By similarity). |
Keyword | Complete proteome; Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 251 AA |
Protein Sequence | MTEAQRHQIL LEMLAQLGFV TVEKVVERLG ISPATARRDI NKLDESGKLK KVRNGAEAIT 60
QQRPRWTPMN LHQAQNHDEK VRIAKAASQL VNPGESVVIN CGSTAFLLGR EMCGKPVQII 120
TNYLPLANYL IDQEHDSVII MGGQYNKSQS ITLSPQGSEN SLYAGHWMFT SGKGLTAEGL 180
YKTDMLTAMA EQKMLSVVGK LVVLVDSSKI GERAGMLFSR ADQIDMLITG KNANPEILQQ 240
LEAQGVSILR V 251 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:HAMAP. GO:0031418; F:L-ascorbic acid binding; IMP:EcoCyc. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro. GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:HAMAP. GO:0006351; P:transcription, DNA-dependent; IEP:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |