CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005062
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein SLY1 
Protein Synonyms/Alias
 Suppressor of loss of YPT1 protein 1 
Gene Name
 SLY1 
Gene Synonyms/Alias
 YDR189W; YD9346.01; YD9395.22 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
312GTDNTTAKPLATKKYubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Able to suppress the functional loss of YPT1. SLY1 is essential for cell viability. May interact indirectly, or directly with YPT1. 
Sequence Annotation
 REPEAT 106 142 1.
 REPEAT 220 257 2.
 REPEAT 436 474 3.
 REPEAT 478 514 4.
 REGION 106 514 4 X approximate repeats.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Membrane; Protein transport; Reference proteome; Repeat; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 666 AA 
Protein Sequence
MAVEEIASRK DISLRDMQIS AILKMLFLNK DLNNNDNITT ITDDIFNQQE IIWKVLILDI 60
KSTATISSVL RVNDLLKAGI TVHSLIKQDR SPLPDVPAIY FVSPTKENID IIVNDLKSDK 120
YSEFYINFTS SLPRNLLEDL AQQVSITGKS DKIKQVYDQY LDFIVTEPEL FSLEISNAYL 180
TLNDPKTTEE EITGLCANIA DGLFNTVLTI NSIPIIRAAK GGPAEIIAEK LGTKLRDFVI 240
NTNSSSTSTL QGNDSLERGV LIILDRNIDF ASMFSHSWIY QCMVFDIFKL SRNTVTIPLE 300
SKENGTDNTT AKPLATKKYD IEPNDFFWME NSHLPFPEAA ENVEAALNTY KEEAAEITRK 360
TGVTNISDLD PNSNNDTVQI QEVVKKLPEL TAKKNTIDTH MNIFAALLSQ LESKSLDTFF 420
EVEQDPGSTK TRSRFLDILK DGKTNNLEDK LRSFIVLYLT STTGLPKDFV QNVENYFKEN 480
DYDINALKYV YKLREFMQLS NMSLQNKSLE DGSDSAFKPS NLTLSGIYGL TEGKLQGGVG 540
SLISGIKKLL PEKKTIPITN VVDAIMDPLN SSQKNLETTD SYLYIDPKIT RGSHTRKPKR 600
QSYNKSLVFV VGGGNYLEYQ NLQEWAHSQL HNPKKVMYGS TAITTPAEFL NEISRLGASN 660
SSNNDA 666 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:SGD.
 GO:0030134; C:ER to Golgi transport vesicle; IDA:SGD.
 GO:0000139; C:Golgi membrane; IDA:SGD.
 GO:0019905; F:syntaxin binding; IDA:SGD.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IMP:SGD.
 GO:0035543; P:positive regulation of SNARE complex assembly; IMP:SGD.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0046578; P:regulation of Ras protein signal transduction; IMP:UniProtKB.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IMP:SGD.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro.
 GO:0048280; P:vesicle fusion with Golgi apparatus; IMP:SGD. 
Interpro
 IPR027482; Sec-1-like_dom2.
 IPR001619; Sec1-like. 
Pfam
 PF00995; Sec1 
SMART
  
PROSITE
  
PRINTS