UniProt Accession

 SIAT1_HUMAN; P15907; A8KA14; D3DNV3 

Genbank Protein ID

 X17247; X54363; X62822; AK292879; CH471052; CH471052; CH471052; BC031476; BC040009 

Genbank Nucleotide ID

 CAA35111.1; CAA38246.1; CAA44634.1; BAF85568.1; EAW78161.1; EAW78162.1; EAW78164.1; AAH31476.1; AAH40009.1 

Protein Name

 Beta-galactoside alpha-2,6-sialyltransferase 1 

Protein Synonyms/Alias

 Alpha 2,6-ST 1; B-cell antigen CD75; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1; ST6Gal I; ST6GalI; Sialyltransferase 1 

Gene Name

 ST6GAL1 

Gene Synonyms/Alias

 SIAT1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
177	PKESIRTKAGPWGRC	ubiquitination	[1]
194	VSSAGSLKSSQLGRE	ubiquitination	[1, 2]
226	FQQDVGTKTTIRLMN	ubiquitination	[1, 2]
241	SQLVTTEKRFLKDSL	ubiquitination	[1, 2]
380	LYEKNLVKHLNQGTD	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. 

Sequence Annotation

 MOD_RES 369 369 Phosphotyrosine.
 CARBOHYD 149 149 N-linked (GlcNAc...).
 CARBOHYD 161 161 N-linked (GlcNAc...).
 DISULFID 142 406 By similarity.
 DISULFID 184 335 By similarity.
 DISULFID 353 364 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase; Golgi apparatus; Membrane; Phosphoprotein; Reference proteome; Secreted; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0030173; C:integral to Golgi membrane; IEA:InterPro.
 GO:0003835; F:beta-galactoside alpha-2,6-sialyltransferase activity; IEA:EC.
 GO:0008373; F:sialyltransferase activity; IDA:UniProtKB.
 GO:0006959; P:humoral immune response; TAS:ProtInc.
 GO:0016266; P:O-glycan processing; TAS:Reactome.
 GO:0043687; P:post-translational protein modification; TAS:Reactome.
 GO:0018279; P:protein N-linked glycosylation via asparagine; TAS:Reactome. 

Interpro

 IPR001675; Glyco_trans_29.
 IPR012163; Sialyl_trans. 

Pfam

 PF00777; Glyco_transf_29 

SMART

  

PROSITE

  

PRINTS